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NCT05490186
Function, Pain, and Alignment Following Knee Replacement for the Treatment of Osteoarthritis
NA trial testing Total Knee Replacement in Knee Replacement, Total in 261 participants. Terminated before completion.
8 February 2024
Quick facts
| Lead sponsor | North York General Hospital |
|---|---|
| Phase | NA |
| Status | Terminated |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 261 |
| Start date | 16 November 2021 |
| Primary completion | 8 February 2024 |
| Estimated completion | 8 February 2024 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Total Knee Replacement
Conditions studied
- Knee Replacement, Total — all drugs for Knee Replacement, Total →
- Pain, Postoperative — all drugs for Pain, Postoperative →
- Functional Independence — all drugs for Functional Independence →
Sponsor
North York General Hospital
Who can join
Adults 18 to 80, any sex, with Knee Replacement, Total or Pain, Postoperative. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
There are many factors that can influence patient satisfaction and patient related outcomes following total knee replacement including the surgical alignment of the joint components. Historically, total knee replacements have been performed with an aim aiming to achieve neutral alignment or a mechanical weight axis in the lower extremity . However, only 0.1 % of the population have a pre-surgical anatomical neutral alignment, and therefore the constitutional anatomy of the patient is neglected. There is a growing trend to return patients back their anatomical constitutional alignment after a knee replacement, referred to as Kinematic Alignment using robotics. The aim of this randomized controlled trial is to examine how mechanical alignment and kinematic alignment impacts function, pain, mood and fatigue following TKR for the treatment of osteoarthritis. Outcomes will be measured at 6 week, 6 months, 1 year and 2 years after surgery.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05490186
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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- Google Scholar
Related trials
Other trials of Total Knee Replacement
Trials testing the same drug.
- NCT06118073 — Effect of Mindfulness on Pain After Total Knee Arthroplasty · NA · unknown
- NCT04730271 — Comparison of Alignment Achieved Using the VELYS Robotic-Assisted Solution Versus Manual Instrumentation in Total Knee A · NA · completed
- NCT05038670 — Journey II vs Persona Knee Systems - RCT · NA · completed
- NCT02525562 — Stryker NTX Registry Scorpio NRG (Re-"Energize"), Triathlon Total Knee, Triathlon Partial Knee Resurfacing (PKR) With X3 · NA · terminated
- NCT01497730 — 10003 PRO Current Products · completed
Other North York General Hospital trials
Trials by the same sponsor.
- NCT04437238 — Pilot Evaluation of "KeepWell" Using a Hybrid Effectiveness-Implementation Pragmatic Randomized Controlled Trial · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05490186 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by North York General Hospital
- Last refreshed: 20 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05490186.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing