NCT05487053 is a NA clinical trial of Single-shot adductor canal block in Osteo Arthritis Knee, sponsored by Negovsky Reanimatology Research Institute.

Who is sponsoring NCT05487053?

NCT05487053 is sponsored by Negovsky Reanimatology Research Institute.

What drugs are being tested in NCT05487053?

Interventions in NCT05487053: Single-shot adductor canal block, Continuous femoral nerve block.

What condition does NCT05487053 study?

NCT05487053 studies Osteo Arthritis Knee, Gonarthrosis.

Is NCT05487053 still recruiting?

NCT05487053 is currently recruiting now. Last updated 15 April 2026.

Last reviewed 2026-04-15 · How we verify

NCT05487053

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Impact of Single-shot Adductor Canal Block Versus Continuous Femoral Nerve Block on Rehabilitation After Total Knee Replacement

Recruiting now NA Last updated 15 April 2026

What this trial tests

NA trial testing Single-shot adductor canal block in Osteo Arthritis Knee in 220 participants. Currently enrolling.

Timeline

3 February 2024

Primary endpoint
1 December 2027

1 July 2028

Quick facts

Lead sponsor	Negovsky Reanimatology Research Institute
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	220
Start date	3 February 2024
Primary completion	1 December 2027
Estimated completion	1 July 2028
Sites	1 location across Russia

Drugs / interventions tested

Single-shot adductor canal block
Continuous femoral nerve block

Conditions studied

Osteo Arthritis Knee — all drugs for Osteo Arthritis Knee →
Gonarthrosis — all drugs for Gonarthrosis →

Sponsor

Negovsky Reanimatology Research Institute

Who can join

18 and older, any sex, with Osteo Arthritis Knee or Gonarthrosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Total knee replacement (TKR) is considered the most effective and safe method of radical treatment of late stages of knee osteoarthritis. A well-known problem of TKR is a severe postoperative pain syndrome, which is observed in more than 50% of patients. Femoral nerve block (FNB) is the "gold standard" for continuous postoperative analgesia after total knee replacement, as it is effective in reducing the frequency of use of opioid analgetics and reduce the duration of hospitalization. At the same time, the negative effect of this method is the motor blockade of the quadriceps femoris muscle which leads to functional impairment and is associated with an increased risk of falling. Adductor canal block (ACB) provides adequate analgesia comparable to femoral nerve block. Moreover, ACB doesn't affect the motor function of the quadriceps femoris muscle. The possibility of enhanced recovery after total knee replacement is the reason to compare single-shot adductor canal block and continuous femoral nerve block.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other recruiting trials for Osteo Arthritis Knee

Currently open trials in the same condition.

NCT07258693 — Multimodal Treatment of Knee Osteoarthritis: Therapeutic Exercise and Noninvasive Neuromodulation (NESA) Versus Therapeu · NA · active not recruiting
NCT07141316 — Effects of Blood Flow Restriction Combined With Electrostimulation After Knee Arthroplasty · NA · active not recruiting
NCT06485843 — An Study to Evaluate Safety and Tolerability of OA-SYS in Subjects With Moderate to Severe Osteoarthritis of the Knee Jo · Phase 2 · recruiting
NCT06965946 — Intermittent Hypoxia-Hyperoxia Combined With Physical Therapy for Knee Osteoarthritis · NA · recruiting
NCT06058169 — Effects of Home Base Whole-body Vibration in Osteoarthritis. (VIBE-Rx2) · NA · recruiting

Other Negovsky Reanimatology Research Institute trials

Trials by the same sponsor.

NCT07200180 — Perioperative Argon Inhalation to Improve Neurocognitive Recovery After Carotid Surgery · Phase 3 · recruiting
NCT05259631 — Inhalational (Sevoflurane) Versus Intravenous (Propofol) Sedation in Adults With a Moderate Form of ARDS · Phase 3 · suspended
NCT05209737 — Trendelenburg as a First-line Intervention in Critically Ill, Sedated, Invasively Mechanically Ventilated, Hypotensive P · NA · terminated
NCT05335109 — Neuroprotective Effects of Xenon Treatment in Patients with Cerebral Infarction · Phase 3 · completed
NCT05126238 — A Lithium-Based Medication to Improve Neurological Outcomes After Surgical Carotid Reconstruction · Phase 3 · terminated

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05487053 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Negovsky Reanimatology Research Institute
Last refreshed: 15 April 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05487053.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing