Who is sponsoring NCT05486832?

NCT05486832 is sponsored by Cardiovalve Ltd..

What drugs are being tested in NCT05486832?

Interventions in NCT05486832: Cardiovalve TR valve replacement System.

What condition does NCT05486832 study?

NCT05486832 studies Tricuspid Regurgitation.

Is NCT05486832 still recruiting?

NCT05486832 is currently recruiting now. Last updated 5 January 2026.

Last reviewed 2026-01-05 · How we verify

NCT05486832: TARGET

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

"TARGET Study": Safety and Performance of the Cardiovalve TR Replacement System

Recruiting now NA Last updated 5 January 2026

What this trial tests

NA trial testing Cardiovalve TR valve replacement System in Tricuspid Regurgitation in 100 participants. Currently enrolling.

Timeline

9 December 2022

Primary endpoint
15 August 2026

15 December 2033

Quick facts

Lead sponsor	Cardiovalve Ltd.
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	100
Start date	9 December 2022
Primary completion	15 August 2026
Estimated completion	15 December 2033
Sites	7 locations across Germany

Drugs / interventions tested

Cardiovalve TR valve replacement System

Conditions studied

Tricuspid Regurgitation — all drugs for Tricuspid Regurgitation →

Sponsor

Cardiovalve Ltd. — full company profile →

Who can join

Adults 18 to 85, any sex, with Tricuspid Regurgitation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The objective of this study is to evaluate the safety and performance of Cardiovalve TR system

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

Transcatheter mitral valve implantation for native valve disease.
Urena M, Lurz P, Sorajja P, Himbert D, et al · · 2023 · cited 6× · PMID 37994096 · DOI 10.4244/eij-d-22-00890
Transcatheter tricuspid valve treatment: a growing armamentarium of devices.
Estevez-Loureiro R, Echarte-Morales J, Karam N, Linke A, et al · · 2026 · PMID 42064870 · DOI 10.1093/eurheartjsupp/suaf098
Tricuspid valve edge to edge repair vs replacement - a comparative analysis and future directions.
Hajj J, Kassab J, Zalaquett Z, Harb SC, et al · · 2026 · PMID 40779241 · DOI 10.1080/14796678.2025.2545133
Transcatheter tricuspid valve replacement: will it prevail?
Zhang X, Pommert NS, Meier D, Sellers SL, et al · · 2025 · PMID 40308273 · DOI 10.3389/fcvm.2025.1562658
CardioTwins: case report of a transcatheter mitral and tricuspid valve implantation in one patient.
Schmidt T, Kuck KH, Marquetand C, Eitel I, et al · · 2024 · PMID 39045523 · DOI 10.1093/ehjcr/ytae336

Verify or expand the search:

Other recruiting trials for Tricuspid Regurgitation

Currently open trials in the same condition.

NCT07509658 — TriClip Japan Post-Approval Study · recruiting
NCT07042360 — Application of Comprehensive Non-invasive Assessment To Phenotype Tricuspid Regurgitation · recruiting
NCT06833476 — TTVR STRONG Under Coverage With Evidence Development (CED) Study · recruiting
NCT06836011 — A Multicenter Study on Atrioventricular Regurgitation in Transthyretin Amyloid Cardiomyopathy: Definition, Prevalence, a · recruiting
NCT07085650 — The Multi-center Study of Comprehensive Atrial Fibrillation Regurgitation and Recurrent Events Evaluation · recruiting

Other Cardiovalve Ltd. trials

Trials by the same sponsor.

NCT03339115 — AHEAD: European Feasibility Study of the Cardiovalve Transfemoral Mitral Valve System · NA · active not recruiting
NCT03958773 — Cardiovalve Transfemoral System - FIM Study · NA · enrolling by invitation

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05486832 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Cardiovalve Ltd.
Last refreshed: 5 January 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05486832.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing