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NCT05485051: CLEAN-IT
Daily Chlorexidine Bath for Health Care Associated Infection Prevention
Phase 3 trial testing 2% chlorhexidine digluconate solution with surface-active agents in Health Care Associated Infection in 15,730 participants. Completed in 31 March 2024.
31 March 2024
Quick facts
| Lead sponsor | Hospital do Coracao |
|---|---|
| Phase | Phase 3 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 15,730 |
| Start date | 3 August 2022 |
| Primary completion | 31 March 2024 |
| Estimated completion | 31 March 2024 |
| Sites | 16 locations across Brazil |
Drugs / interventions tested
- 2% chlorhexidine digluconate solution with surface-active agents
- Usual Baths
Conditions studied
- Health Care Associated Infection — all drugs for Health Care Associated Infection →
- Ventilator Associated Pneumonia — all drugs for Ventilator Associated Pneumonia →
- Central Line-associated Bloodstream Infection (CLABSI) — all drugs for Central Line-associated Bloodstream Infection (CLABSI) →
- Catheter-Associated Urinary Tract Infection — all drugs for Catheter-Associated Urinary Tract Infection →
Sponsor
Hospital do Coracao
Who can join
18 and older, any sex, with Health Care Associated Infection or Ventilator Associated Pneumonia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Cluster randomized controlled trial comparing two bathing strategies in critically ill patients. The intervention group will receive daily bathing with chlorhexidine. The control group will receive usual care.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Brazilian Research in Intensive Care Network (BRICNet): shaping the landscape of critical care research in Brazil and beyond.
Ferreira JC, Pereira AJ, Pereira AJ, Cavalcanti AB, et al · · 2025 · cited 1× · PMID 40561345 · DOI 10.62675/2965-2774.20250284 -
Daily Chlorhexidine Bath for Health Care Associated Infection Prevention (CLEAN-IT): protocol for a multicenter cluster randomized crossover open-label trial.
Tomazini BM, Veiga TS, Santos RHN, Campos VB, et al · · 2024 · cited 1× · PMID 39356897 · DOI 10.62675/2965-2774.20240053-en -
Daily Chlorhexidine Bathing for the Prevention of Nosocomial Infections in Critically Ill Patients (CLEAN-IT): a multicentre, cluster-randomised, crossover trial.
Tomazini BM, Besen BAMP, Gales AC, Bianchini L, et al · · 2026 · PMID 41732706 · DOI 10.1016/j.lana.2026.101400
Verify or expand the search:
- PubMed search for NCT05485051
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Health Care Associated Infection
Currently open trials in the same condition.
- NCT06514131 — Water Hygiene Versus Waterless Hygiene Technology for Totally Dependent Hospitalized Patients · NA · recruiting
- NCT05756582 — Prevalence of Latent Tuberculosis Infection in Health-care Workers and Students · recruiting
Other Hospital do Coracao trials
Trials by the same sponsor.
- NCT07534163 — III Brazilian Registry of Heart Failure · not yet recruiting
- NCT07129733 — Oral Care Layered Enhancement for Improved Oral Hygiene in Intensive Care Units · NA · not yet recruiting
- NCT07037524 — Low Dose Radiotherapy for Heart Failure · Phase 1, PHASE2 · not yet recruiting
- NCT06546137 — National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Un · recruiting
- NCT06547892 — Use of Vasopressin in Patients at High Risk of Acute Kidney Injury Admitted to the ICU · Phase 2 · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05485051 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospital do Coracao
- Last refreshed: 13 June 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05485051.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing