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NCT05483257

Molecular Subtyping for Prognosis Evaluation in Resected Pancreatic Adenocarcinoma

Completed Last updated 2 August 2022
What this trial tests

trial testing Multigene panel for next-generation sequencing in Pancreatic Cancer Resectable in 226 participants. Completed in 13 September 2021.

Timeline
14 March 2018
Primary endpoint
3 August 2020
13 September 2021

Quick facts

Lead sponsorBAIYONG SHEN
StatusCompleted
Study typeOBSERVATIONAL
Enrollment226
Start date14 March 2018
Primary completion3 August 2020
Estimated completion13 September 2021
Sites1 location across China

Drugs / interventions tested

Conditions studied

Sponsor

BAIYONG SHEN

Who can join

Adults 34 to 84, any sex, with Pancreatic Cancer Resectable. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Pancreatic adenocarcinoma (PAAD) patients following surgeries are prone to relapse shortly, while it is not well understood by current biomarkers. Given the potential associations of human leukocyte antigen class I (HLA-I) genotype with oncogenic mutational profile and immunotherapy efficacy, we aimed to assess whether differential HLA-I genotype could predict the postoperative outcomes in resected PAAD patients.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. Specific human leukocyte antigen class I genotypes predict prognosis in resected pancreatic adenocarcinoma: a retrospective cohort study.
    Wen C, Zhang L, Yang Y, Jin Y, et al · · 2023 · cited 2× · PMID 37026827 · DOI 10.1097/js9.0000000000000264

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