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Protein and Exercise Training in Chronic KIDNEY Disease (PET KIDNEY)
When patients progress to the final stage of chronic kidney disease (CKD) and require hemodialysis treatment, they typically have lost so much muscle function that they are no longer physically independent. However, due to disease- and hemodialysis-related muscle catabolism, dietary protein and exercise interventions are only capable to attenuate the decline in physical function of patients on hemodialysis treatment. Therefore, lifestyle interventions to increase muscle function should be implemented before hemodialysis is required. However, it is still a matter of debate whether muscle protein synthesis rates of patients with advanced CKD can be increased with a patient-tailored dietary protein and exercise intervention.Therefore, the current study will assess MPS rates during habitual lifestyle and during an interventional program including dietary protein and exercise in patients with advanced CKD. In addition, we will compare MPS rates during free-living conditions between patients with advanced CKD and healthy controls.
Details
| Lead sponsor | Maastricht University Medical Center |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 40 |
| Start date | Sun Jan 01 2023 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Mon Dec 02 2024 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Kidney Diseases
- Muscle Loss
Interventions
- Whey protein
Countries
Netherlands