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NCT05482178
The Association of Resistance Exercise With the Inflammasome Activation in Obesity Subjects
NA trial testing Resistance exercise training plus hypocaloric diet in Physical Activity in 20 participants. Status unknown.
15 August 2022
Quick facts
| Lead sponsor | Elisa Barron-Cabrera |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 20 |
| Start date | 31 May 2022 |
| Primary completion | 15 August 2022 |
| Estimated completion | 16 December 2022 |
| Sites | 1 location across Mexico |
Drugs / interventions tested
- Resistance exercise training plus hypocaloric diet
- Hypocaloric diet
Conditions studied
- Physical Activity — all drugs for Physical Activity →
- Resistance Exercise — all drugs for Resistance Exercise →
- Inflammation — all drugs for Inflammation →
- Obesity — all drugs for Obesity →
Sponsor
Elisa Barron-Cabrera
Who can join
Adults 25 to 50, any sex, with Physical Activity or Resistance Exercise. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The intervention study consist in 3 months of follow up to evaluate the effect of resistance exercise on NLRP3 and interleukin-18 (IL-18) gene expression, and IL-18 and IL-1b cytokines levels in obese subjects, due to, the current evidence has been suggested that aerobic physical exercise could reduce the low-grade chronic inflammation through the downregulation of the NLRP3 inflammasome in obesity subjects, however, there are not enough evidence with resistance protocol. The investigator randomized into two intervention groups: a) group with resistance exercise training plus hypocaloric diet, and b) group with hypocaloric diet. The blood sample was taken fasting at baseline and final intervention (3rd month). The serum was separated for biochemical analyzes and the quantification of cytokines levels. The RNA was obtained from leukocytes to expression assay.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
NLRP3 inflammasome: a key player in the pathogenesis of life-style disorders.
Ramachandran R, Manan A, Kim J, Choi S. · · 2024 · cited 67× · PMID 38945951 · DOI 10.1038/s12276-024-01261-8
Verify or expand the search:
- PubMed search for NCT05482178
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05482178 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Elisa Barron-Cabrera
- Last refreshed: 1 August 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05482178.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing