Last reviewed · How we verify
NCT05481047
Prevention or Treatment of Arterial Hypotension and Oxygen Cerebral Saturation During Major Abdominal Surgery
NA trial testing HPI in Hypotension During Surgery in 48 participants. Completed in 22 March 2024.
1 April 2023
Quick facts
| Lead sponsor | Fondazione Policlinico Universitario Agostino Gemelli IRCCS |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 48 |
| Start date | 1 September 2022 |
| Primary completion | 1 April 2023 |
| Estimated completion | 22 March 2024 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- HPI
Conditions studied
- Hypotension During Surgery — all drugs for Hypotension During Surgery →
- Hemodynamic Instability — all drugs for Hemodynamic Instability →
Sponsor
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Who can join
65 and older, any sex, with Hypotension During Surgery or Hemodynamic Instability. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In this study investigators will explore the association between intraoperative arterial hypotension and cerebral oxygen saturation in patients scheduled for major abdominal surgery. Investigators will assign patients to control or interventional group. In this last group arterial hypotension will be avoided based on a HPI (Hypotension Predictive Index) protocol. In the control group arterial hypotension will be promptly treated according to hemodynamic variables.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05481047
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of HPI
Trials testing the same drug.
- NCT06871150 — Three Different GHDT ( Goal Hemodynamic Directed Therapy) Strategies for Intraoperative Fluid Management Optimization Du · NA · recruiting
- NCT07405892 — Applying HPI in Oral Cancer Surgery · NA · not yet recruiting
Other recruiting trials for Hypotension During Surgery
Currently open trials in the same condition.
- NCT07328958 — Effect of Titrated Administration of Ciprofol on Perioperative Hypotension in Elderly Patients Undergoing Laparoscopic A · NA · recruiting
- NCT07052864 — IV Dexamethasone in Preventing Post Spinal Hypotension · Phase 4 · active not recruiting
- NCT07022210 — Incidence of Hypotension in the Post-anesthesia Care Unit (PACU). · recruiting
- NCT06952907 — Femoral Versus Radial Invasive Arterial Pressure Monitoring in Cardiac Surgery Patients · NA · recruiting
- NCT07094321 — Study on the Correlation Between Intraoperative Hypotension and Postoperative Myocardial Injury · active not recruiting
Other Fondazione Policlinico Universitario Agostino Gemelli IRCCS trials
Trials by the same sponsor.
- NCT07514572 — Impact of Estimated Weight and Height on Nutritional Assessment in Elderly · NA · not yet recruiting
- NCT07504679 — Adipose Visceral and Epicardial Risk Evaluation · NA · not yet recruiting
- NCT07520643 — MISTIC Study: Atherosclerosis, Neurocognition & Cardiovascular Signaling · not yet recruiting
- NCT07479238 — Breath Test-Based Assessment of SIBO in Chronic Pancreatitis and Partial Pancreatectomy · not yet recruiting
- NCT07494227 — Development of the SC-IBD Self-Care Measurement Scale · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05481047 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Last refreshed: 5 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05481047.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing