NCT05470959 (BIRCRMGILYCT) is a NA clinical trial of ACTIVA bioactive in Dental Caries, sponsored by Mansoura University.

Who is sponsoring NCT05470959?

NCT05470959 is sponsored by Mansoura University.

What drugs are being tested in NCT05470959?

Interventions in NCT05470959: ACTIVA bioactive, Riva LC.

What condition does NCT05470959 study?

NCT05470959 studies Dental Caries.

Is NCT05470959 still recruiting?

NCT05470959 is currently completed. Last updated 22 July 2022.

Last reviewed 2022-07-22 · How we verify

NCT05470959: BIRCRMGILYCT

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Bioactive Composite Versus Resin-Modified Glass Ionomer Liners: 2-Year Clinical Trial

Completed NA Last updated 22 July 2022

What this trial tests

NA trial testing ACTIVA bioactive in Dental Caries in 20 participants. Completed in 20 December 2021.

Timeline

10 October 2019

Primary endpoint
30 October 2021

20 December 2021

Quick facts

Lead sponsor	Mansoura University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	treatment
Enrollment	20
Start date	10 October 2019
Primary completion	30 October 2021
Estimated completion	20 December 2021
Sites	1 location across Egypt

Drugs / interventions tested

ACTIVA bioactive
Riva LC

Conditions studied

Dental Caries — all drugs for Dental Caries →

Sponsor

Mansoura University

Who can join

Adults 20 to 50, any sex, with Dental Caries. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

compare 2-year clinical performance of recent bioactive ionic resin composite to resin-modified glass ionomer liner in indirect dental pulp treatment.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Bioactive restorative materials in dentistry: a comprehensive review of mechanisms, clinical applications, and future directions.
Abozaid D, Azab A, Bahnsawy MA, Eldebawy M, et al · · 2026 · cited 8× · PMID 40819015 · DOI 10.1007/s10266-025-01162-w
3-year randomized clinical trial to evaluate the performance of posterior composite restorations lined with ion-releasing materials.
Ahmed B, Wafaie RA, Hamama HH, Mahmoud SH. · · 2024 · cited 6× · PMID 38418863 · DOI 10.1038/s41598-024-55329-6

Verify or expand the search:

Other recruiting trials for Dental Caries

Currently open trials in the same condition.

NCT06787261 — Involvement of Archaea in Carious Disease · NA · recruiting
NCT06753669 — Mothers' Action Project for Child Health · NA · recruiting
NCT07431463 — Effects of Different Remineralization Agents on the Progression of Non-Cavitated Approximal Carious Lesions in Primary T · NA · active not recruiting
NCT07134114 — Occlusal Impact of Hall Crowns in Primary Molars · NA · recruiting
NCT07181967 — SDF vs Fluoride Varnish for Streptococcus Mutans Reduction in Children · NA · recruiting

Other Mansoura University trials

Trials by the same sponsor.

NCT05785377 — Neostigmine as an Adjuvant in Tranversus Abdominis Plane (TAP) Block in Cesarean Section Under Spinal Anesthesia · NA · not yet recruiting
NCT07509567 — Conventional Palatal Crib Versus Bonded Spurs for Anterior Open Bite Treatment · NA · not yet recruiting
NCT07393178 — Efficacy & Safety of High Power vs. Low Power Holmium Laser in Mini-PCNL for Large Renal Stones · NA · not yet recruiting
NCT07436182 — Mitochondrial Redox Modulation in Newly Diagnosed Type 2 Diabetes: A Randomized Controlled Trial Comparing Imeglimin vs. · Phase 4 · not yet recruiting
NCT07534943 — Effectiveness of Oleanolic Acid as Intracanal Medicament on Infectious/Inflammatory Contents in Teeth With Apical Period · NA · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05470959 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Mansoura University
Last refreshed: 22 July 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05470959.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing