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NCT05467163: CONDUCT-AF
Conduction System Pacing Versus Biventricular Pacing After Atrioventricular Node Ablation
NA trial testing Biventricular pacemaker implantation in Heart Failure in 82 participants. Currently enrolling.
25 December 2025
Quick facts
| Lead sponsor | University Medical Centre Ljubljana |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 82 |
| Start date | 18 July 2023 |
| Primary completion | 25 December 2025 |
| Estimated completion | 25 December 2026 |
| Sites | 10 locations across Belgium, Austria, Hungary, Romania, Slovenia, Bulgaria, Croatia |
Drugs / interventions tested
- Biventricular pacemaker implantation
- Conduction system pacing device implantation
- AV node ablation
Conditions studied
- Heart Failure — all drugs for Heart Failure →
- Tachycardia-induced Cardiomyopathy — all drugs for Tachycardia-induced Cardiomyopathy →
- Atrial Fibrillation — all drugs for Atrial Fibrillation →
Sponsor
University Medical Centre Ljubljana
Who can join
Adults 18 to 85, any sex, with Heart Failure or Tachycardia-induced Cardiomyopathy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Atrioventricular node ablation (AVNA) with biventricular (BiV) pacemaker implantation is a feasible treatment option in patients with symptomatic refractory atrial fibrillation and heart failure. However, conduction system pacing (CSP) modalities, including His bundle pacing and left bundle branch pacing, could offer advantages over BiV pacing by providing more physiological activation. The randomized, interventional, multicentric study will explore whether CSP is non-inferior to BiV pacing in echocardiographic and clinical outcomes in heart failure (EF \<50%) patients with symptomatic AF and narrow QRS scheduled for AVNA.
Publications & conference data
5 peer-reviewed publications reference this trial (live from Europe PMC):
-
Current Role of Conduction System Pacing in Patients Requiring Permanent Pacing.
Beer D, Vijayaraman P. · · 2024 · cited 4× · PMID 38859643 · DOI 10.4070/kcj.2024.0113 -
Paradigm Shifts in Cardiac Pacing: Where Have We Been and What Lies Ahead?
Ballantyne BA, Chew DS, Vandenberk B. · · 2023 · cited 3× · PMID 37109274 · DOI 10.3390/jcm12082938 -
Is Conduction System Pacing a Valuable Alternative to Biventricular Pacing for Cardiac Resynchronization Therapy?
Castagno D, Zanon F, Pastore G, De Ferrari GM, et al · · 2024 · cited 2× · PMID 38786966 · DOI 10.3390/jcdd11050144 -
The CONDUCT-AF trial: Rationale and design of a prospective, randomized, multicentre study comparing conduction system and biventricular pacing in patients undergoing atrioventricular node ablation for heart failure with atrial fibrillation.
Ivanovski M, Mrak M, Mežnar AZ, Jan M, et al · · 2025 · cited 1× · PMID 40920457 · DOI 10.1002/ejhf.70013 -
Cardiac Resynchronization Therapy and Conduction System Pacing.
O'Neill TG, Tsushima T, Tayal B. · · 2025 · cited 1× · PMID 40364243 · DOI 10.3390/jcm14093212
Verify or expand the search:
- PubMed search for NCT05467163
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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Other University Medical Centre Ljubljana trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05467163 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Medical Centre Ljubljana
- Last refreshed: 15 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05467163.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing