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NCT05466669
Prediction of Post-TIPS Hepatic Encephalopathy in Patients With Liver Cirrhosis
trial in Hepatic Encephalopathy in 83 participants. Status unknown.
10 February 2025
Quick facts
| Lead sponsor | Johannes Gutenberg University Mainz |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 83 |
| Start date | 9 March 2022 |
| Primary completion | 10 February 2025 |
| Estimated completion | 10 February 2025 |
| Sites | 2 locations across Germany |
Conditions studied
- Hepatic Encephalopathy — all drugs for Hepatic Encephalopathy →
- Liver Cirrhosis — all drugs for Liver Cirrhosis →
Sponsor
Johannes Gutenberg University Mainz
Who can join
18 and older, any sex, with Hepatic Encephalopathy or Liver Cirrhosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Prediction of hepatic encephalopathy after insertion of a transjugular intrahepatic portosystemic stent shunt (post-TIPS HE) are critical for patient selection prior to TIPS insertion, and a currently unmet, clinically highly relevant need. In this prospective multicenter observational cohort study, the investigators aim to evaluate the ability of Stroop EncephalApp and the simplified Animal Naming Test (S-ANT1) in comparison to the goldstandard PHES to predict the occurence of post-TIPS HE in patients with decompensated liver cirrhosis. Moreover, secondary aims of this study include the detection of potential blood based biomarkers for prediction of post-TIPS HE and the predictive value of frailty and quality of life/sleep prior to TIPS insertion.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Impact of Frailty on the Prognosis of Patients With Liver Cirrhosis Undergoing Insertion of a TIPS.
Kabelitz MA, Gairing SJ, Tiede A, Schleicher EM, et al · · 2026 · cited 2× · PMID 40751304 · DOI 10.1111/apt.70315 -
Neurofilament Light Chains in Serum Predict Post-Transjugular Intrahepatic Portosystemic Shunt Hepatic Encephalopathy.
Labenz C, Schleicher EM, Meineck M, Kabelitz MA, et al · · 2025 · PMID 41200277 · DOI 10.1002/mco2.70475
Verify or expand the search:
- PubMed search for NCT05466669
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Hepatic Encephalopathy
Currently open trials in the same condition.
- NCT07521332 — Apixaban-PK Trial: Preventing Portal Hypertension Complications in Cirrhosis · Phase 4 · recruiting
- NCT07418008 — The Liver Cirrhosis Cognitive Decline Scale (LiCCoS) · recruiting
- NCT06953921 — Correlation Between Serum Albumin Level and Severity of Hepatic Encephalopathy in Patients With Chronic Liver Disease in · recruiting
- NCT07437638 — Clinical Efficacy and Survival Prediction Analysis of Transjugular Intrahepatic Portosystemic Shunt in Patients With Liv · active not recruiting
- NCT06425380 — Pilot Open-Label Trial of Resistant Potato Starch in Patients With Cirrhosis and Overt Hepatic Encephalopathy · NA · recruiting
Other Johannes Gutenberg University Mainz trials
Trials by the same sponsor.
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- NCT06739993 — Effects of Autonomic Nervous System Modulation by Heart Rate Variability Biofeedback Training With Resonant Frequency Br · NA · recruiting
- NCT06514495 — Differential Effects of in Vivo and Virtual Exposure Therapy in Agoraphobia · NA · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05466669 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Johannes Gutenberg University Mainz
- Last refreshed: 20 July 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05466669.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing