NCT05466344 is a Phase 2, PHASE3 clinical trial of Herbst Group in Class II Malocclusion, sponsored by Al-Azhar University.

Who is sponsoring NCT05466344?

NCT05466344 is sponsored by Al-Azhar University.

What drugs are being tested in NCT05466344?

Interventions in NCT05466344: Herbst Group, TFBC Group.

What condition does NCT05466344 study?

NCT05466344 studies Class II Malocclusion.

Is NCT05466344 still recruiting?

NCT05466344 is currently completed. Last updated 21 July 2022.

Last reviewed 2022-07-21 · How we verify

NCT05466344

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

the Condylar Response of Mini-plate Anchored Rigid Fixed Functional Appliance Versus Dentally Anchored Semi-rigid One

Completed Phase 2, PHASE3 Last updated 21 July 2022

What this trial tests

Phase 2, PHASE3 trial testing Herbst Group in Class II Malocclusion in 20 participants. Completed in 15 April 2022.

Timeline

15 June 2020

Primary endpoint
10 March 2022

15 April 2022

Quick facts

Lead sponsor	Al-Azhar University
Phase	Phase 2, PHASE3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	20
Start date	15 June 2020
Primary completion	10 March 2022
Estimated completion	15 April 2022
Sites	1 location across Egypt

Drugs / interventions tested

Herbst Group
TFBC Group

Conditions studied

Class II Malocclusion — all drugs for Class II Malocclusion →

Sponsor

Al-Azhar University

Who can join

Adults 18 to 20, any sex, with Class II Malocclusion. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will be directed to evaluate The effect of two different types of fixed functional appliances on the temporomandibular joint. Study design: Prospective randomized clinical study. Study setting and population: This study will be conducted on twenty orthodontic patients. The number of patients was dependent on a power study. Sample size calculation was based on the observed average effect size derived from previous article addressing "the effect of skeletally anchored Forsus FRD using miniplates for the treatment of Class II malocclusion

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Assessment of the condylar response of two differently anchored fixed functional appliances in class II malocclusion in young adult orthodontic patients: A randomized clinical trial.
Abo-Elmahasen MMF, Elsaharty M, Abotaha NF, Mohamed AAS. · · 2024 · PMID 38516116 · DOI 10.4103/jos.jos_112_23

Verify or expand the search:

Other trials of Herbst Group

Trials testing the same drug.

NCT05440526 — the Mini-plate Anchored Herbst Appliance Versus the Dentally Anchored Fixed Functional Appliance · Phase 2, PHASE3 · completed

Other recruiting trials for Class II Malocclusion

Currently open trials in the same condition.

NCT05684510 — Treatment of Mild Class II Malocclusion in Adult Patients With Clear Aligners Versus Fixed Multibracket Therapy · NA · recruiting
NCT07340242 — Dentoskeletal Effects of 3D-Printed Fixed Twin Block Versus MARA Appliances in Management of Skeletal Class II · NA · recruiting
NCT07361172 — Ready-made vs. Custom-made Carriere Motion Appliance · NA · recruiting
NCT06511219 — Maxillary Segmental Distalization Using Digitally Printed Appliances · NA · recruiting
NCT06651944 — Invisalign® System with Mandibular Advancement · NA · recruiting

Other Al-Azhar University trials

Trials by the same sponsor.

NCT06489327 — Comparing Two Doses of Oral Melatonin as Premedication in Children Undergoing Surgery · NA · recruiting
NCT07327918 — Effect of Epidural Needle Injection on Catheter Placement Success During Painless Labour · Phase 3 · not yet recruiting
NCT07500194 — Quad Helix vs RME for Posterior Cross-bite in Egyptian Children · NA · not yet recruiting
NCT07360756 — Ultrasonographic ONSD as a Predictor of PDPH in Spinal Anesthesia for Cesarean Delivery · not yet recruiting
NCT07343570 — Comparison of Quadratus Lumborum and Combined Groin Nerve Blocks for Postoperative Analgesia After Open Inguinal Hernia · Phase 3 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05466344 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Al-Azhar University
Last refreshed: 21 July 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05466344.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing