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NCT05465330
Effects of Desflurane-propofol Balanced Anesthesia on Visual Evoked Potentials Monitoring
NA trial testing Desflurane in Visual Evoked Potentials in 70 participants. Completed in 21 April 2023.
21 April 2023
Quick facts
| Lead sponsor | Beijing Tiantan Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | prevention |
| Enrollment | 70 |
| Start date | 20 July 2022 |
| Primary completion | 21 April 2023 |
| Estimated completion | 21 April 2023 |
| Sites | 1 location across China |
Drugs / interventions tested
- Desflurane (DESFLURANE) — full drug profile →
- Desflurane, Propofol — full drug profile →
Conditions studied
- Visual Evoked Potentials — all drugs for Visual Evoked Potentials →
Sponsor
Beijing Tiantan Hospital
Who can join
Adults 18 to 65, any sex, with Visual Evoked Potentials. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Intraoperative flash visual evoked potentials (FVEPs) can be used to monitor the integrity of the visual pathway in real-time during surgeries, and is to prevent the damage and deterioration of visual function caused by visual pathway damage, which is the key method of intraoperative monitoring of visual function. Spinal surgery in the prone position may compress the eyeball and reduce the blood supply of the ophthalmic artery, which is still one of the main causes of postoperative visual impairment. Intraoperative FVEPs monitoring is easily affected by inhale anesthetics, and there is little studies on the effect of intravenous-inhalation balanced anesthesia on FVEPs monitoring. Desflurane wakes up quickly, which is conducive to the recovery of early respiratory function and orientation, and early neurological evaluation. This study aims to compare the effects of desflurane-propofol balanced anesthesia and desflurane pure inhalation anesthesia on the amplitude and latency of FVEPs during spinal surgery under the same sedation depth monitored by bispectral index (BIS) monitoring.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effect of desflurane anesthesia on flash visual evoked potential monitoring in patients undergoing spine surgery: study protocol for a randomized controlled trial.
Ma J, Wang J, Li Y, Fu Y, et al · · 2024 · cited 1× · PMID 38840210 · DOI 10.1186/s13063-024-08211-9
Verify or expand the search:
- PubMed search for NCT05465330
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Desflurane
Trials testing the same drug.
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- NCT07511634 — Comparison of Sevoflurane and Desflurane on ANI in Patients Undergoing General Anesthesia: a Prospective Randomized Cont · NA · not yet recruiting
- NCT07440758 — Low-Flow Sevoflurane and Desflurane Anesthesia in Laparoscopic Cholecystectomy · NA · not yet recruiting
- NCT07295158 — Effect of Sevoflurane vs Desflurane on Mechanical Power in Laparoscopic Cholecystectomy · NA · recruiting
- NCT07123870 — Effect of Combined Intravenous-Inhalational Anesthesia (CIVIA) on Postoperative Recovery Patterns. · Phase 4 · recruiting
Other Beijing Tiantan Hospital trials
Trials by the same sponsor.
- NCT07341854 — Dexamethasone Palmitate for Postoperative Pain · NA · not yet recruiting
- NCT07527013 — Stratified Blood Pressure Management Strategy After Endovascular Treatment for Acute Ischemic Stroke · Phase 3 · not yet recruiting
- NCT07520370 — Effect of Perioperative Ulinastatin on Postoperative Stroke in Patients With Brain Tumor · NA · not yet recruiting
- NCT07526987 — Efficacy and Safety of Minocycline in Patients With Acute Ischaemic Stroke Receiving Intravenous Thrombolysis · Phase 3 · not yet recruiting
- NCT07591207 — The Efficacy and Safety of Loxoprofen Sodium Patch in Relieving Postoperative Pain After Laparoscopic Surgery · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05465330 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Beijing Tiantan Hospital
- Last refreshed: 24 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05465330.
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