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NCT05464849
Evaluation of Systemic Microvascular Reactivity in Patients With Resistant Hypertension
trial testing Evaluation of systemic skin microvascular endothelial function in Arterial Hypertension in 111 participants. Completed in 30 December 2025.
30 December 2025
Quick facts
| Lead sponsor | National Institute of Cardiology, Laranjeiras, Brazil |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 111 |
| Start date | 20 December 2021 |
| Primary completion | 30 December 2025 |
| Estimated completion | 30 December 2025 |
| Sites | 1 location across Brazil |
Drugs / interventions tested
- Evaluation of systemic skin microvascular endothelial function
Conditions studied
- Arterial Hypertension — all drugs for Arterial Hypertension →
- Resistant Hypertension — all drugs for Resistant Hypertension →
- Microvascular Rarefaction — all drugs for Microvascular Rarefaction →
- Endothelial Dysfunction — all drugs for Endothelial Dysfunction →
Sponsor
National Institute of Cardiology, Laranjeiras, Brazil
Who can join
Adults 18 to 75, any sex, with Arterial Hypertension or Resistant Hypertension. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Systemic arterial hypertension is a serious health problem worldwide. In some cases, it can phenotypically present as resistant arterial hypertension, which consists of blood pressure levels outside the treatment goals in patients using three or more classes of antihypertensive drugs, one of which is preferably a thiazide diuretic. Resistant hypertension contributes to a 47% higher risk of developing cardiovascular events when compared to patients with non-resistant hypertension. It is known that the microcirculation plays a relevant role in the pathophysiology of arterial hypertension. Furthermore, it is known that the cutaneous microvascular network is an adequate model and that it reflects the systemic microcirculation. In this sense, the present research proposes the study of cutaneous capillary density - through high resolution intravital microscopy - and of the endothelium-dependent and independent microvascular vasodilator response - by the speckle laser flowmetry method coupled to a pharmacological system of micro- iontophoresis - in patients diagnosed with resistant hypertension, with the aim of identifying changes in comparison with patients with non-resistant hypertension and normotensive individuals. Additionally, the evaluation of the association between systemic microvascular function and the presence of target organ lesions in this population may indicate that this is a new non-invasive way of stratifying cardiovascular risk in these individuals.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Reduced systemic microvascular function in patients with resistant hypertension and microalbuminuria: an observational study.
Crahim V, Verri V, De Lorenzo A, Tibirica E. · · 2024 · cited 3× · PMID 39289473 · DOI 10.1038/s41371-024-00958-7
Verify or expand the search:
- PubMed search for NCT05464849
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Other National Institute of Cardiology, Laranjeiras, Brazil trials
Trials by the same sponsor.
- NCT05728047 — Evaluation of Systemic Microcirculation of Patients Undergoing Heart Valve Surgery · completed
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- NCT05864729 — The Association Between Systemic Microvascular Endothelial Function and Coronary Physiology Indexes · NA · completed
- NCT04406545 — Microvascular Flow and Reactivity in Patients Presenting in the Acute Phase of COVID-19. · completed
- NCT05575895 — Evaluation of Systemic Microvascular Reactivity After Ingestion of an Energy Drink in Young Male Volunteers · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05464849 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by National Institute of Cardiology, Laranjeiras, Brazil
- Last refreshed: 13 April 2026
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