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NCT05463393
Xanthohumol as an Adjuvant Therapy in Critically Ill COVID-19 Patients
EARLY_PHASE1 trial testing Xanthohumol - prenylated chalcone extracted from female inflorescences of hop cones (Humulus lupus). Hop-RXn™, BioActive-Tech Ltd, Lublin, Poland; http://xanthohumol.com.pl/ in COVID-19 Respiratory Infection in 50 participants. Suspended.
30 January 2022
Quick facts
| Lead sponsor | Medical University of Lublin |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | Suspended |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | single group |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 50 |
| Start date | 1 October 2020 |
| Primary completion | 30 January 2022 |
| Estimated completion | 31 December 2025 |
| Sites | 1 location across Poland |
Drugs / interventions tested
- Xanthohumol - prenylated chalcone extracted from female inflorescences of hop cones (Humulus lupus). Hop-RXn™, BioActive-Tech Ltd, Lublin, Poland; http://xanthohumol.com.pl/
Conditions studied
- COVID-19 Respiratory Infection — all drugs for COVID-19 Respiratory Infection →
Sponsor
Medical University of Lublin
Who can join
18 and older, any sex, with COVID-19 Respiratory Infection. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
It has been well documented that coronavirus COVID-19 disease is associated with massive inflammatory response and cytokine storm. Several medications have been used to ameliorate COVID-19-related inflammation. Xanthohumol, a natural medication extracted from hop cones, possesses strong anti-inflammatory properties and can reduce the severity of inflammatory response. The aim of this study is to analyze the effect of Xanthohumol on clinical course, inflammatory response and outcome in patients admitted to the ICU due to COVID-related acute respiratory failure with an oxygenation index (PaO2/FiO2) less than 150.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Humulus lupus extract rich in xanthohumol improves the clinical course in critically ill COVID-19 patients.
Dabrowski W, Gagos M, Siwicka-Gieroba D, Piechota M, et al · · 2023 · cited 10× · PMID 36508996 · DOI 10.1016/j.biopha.2022.114082 -
Advancing Brain Health Naturally: β-Caryophyllene and Xanthohumol as Neuroprotective Agents.
Ivanova S, Dzhakova Z, Todorova V, Boyuklieva R, et al · · 2025 · cited 1× · PMID 41011595 · DOI 10.3390/molecules30183702
Verify or expand the search:
- PubMed search for NCT05463393
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05463393 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Medical University of Lublin
- Last refreshed: 1 July 2025
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