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NCT05461820
Effects of Different Treatment Schemes on the Regulation and Recurrence of Graves' Disease
Phase 4 trial testing Methimazole in Graves Disease in 240 participants. Currently enrolling.
31 December 2023
Quick facts
| Lead sponsor | The First Affiliated Hospital with Nanjing Medical University |
|---|---|
| Phase | Phase 4 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 240 |
| Start date | 1 May 2018 |
| Primary completion | 31 December 2023 |
| Estimated completion | 31 July 2030 |
| Sites | 1 location across China |
Drugs / interventions tested
- Methimazole — full drug profile →
Conditions studied
- Graves Disease — all drugs for Graves Disease →
- Relapse — all drugs for Relapse →
- Treatment — all drugs for Treatment →
- Drug Withdrawal — all drugs for Drug Withdrawal →
Sponsor
The First Affiliated Hospital with Nanjing Medical University
Who can join
Adults 18 to 65, any sex, with Graves Disease or Relapse. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In this study, the dose of methimazole was adjusted according to the different states of thyroid function, and the effects of conventional therapy and intensive therapy on the cumulative recurrence of Graves' hyperthyroidism after two years of drug withdrawal were evaluated. At the same time, the changes of immune indexes and inflammatory factors in the regulation process were evaluated. This study is a phase IV clinical study designed and carried out by the First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), which is a randomized, open and routine treatment group with parallel control.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Serum metabolomics reveals systemic metabolic alterations of Graves' disease before and after antithyroid drug treatment.
Li T, Li L, Wang X, Li Y, et al · · 2025 · PMID 40465360 · DOI 10.1530/ec-25-0078
Verify or expand the search:
- PubMed search for NCT05461820
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Methimazole
Trials testing the same drug.
- NCT07369063 — Impact of Vitamin D Therapy on Thyroid Function and Antibody Levels in Pediatric Graves' Disease · Phase 2 · recruiting
- NCT04776993 — A Conservative vs an Ablative Approach for Treatment of Hyperthyroidism in Patients With Graves' Orbitopathy · Phase 3 · unknown
- NCT05017610 — Inducing a Hypothyroxinemic State in Patients With Recurrent Glioblastoma or Gliosarcoma · EARLY_PHASE1 · withdrawn
- NCT05118542 — Effect of Hyperthyroidism and Its Treatment in Graves' Disease to Early Marker of Atherosclerosis · Phase 3 · completed
Other recruiting trials for Graves Disease
Currently open trials in the same condition.
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- NCT07305818 — NEXUS Study: A Study to Test Single and Multiple Doses of MER511 Given to Adults With Graves' Disease · Phase 1 · recruiting
- NCT07286656 — A Study of GensSci098 in Subjects With Graves' Disease · Phase 1 · recruiting
- NCT07129642 — Allogeneic Anti-CD19 CAR-T for Refractory Graves' Disease · EARLY_PHASE1 · recruiting
- NCT07369063 — Impact of Vitamin D Therapy on Thyroid Function and Antibody Levels in Pediatric Graves' Disease · Phase 2 · recruiting
Other The First Affiliated Hospital with Nanjing Medical University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05461820 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The First Affiliated Hospital with Nanjing Medical University
- Last refreshed: 11 December 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05461820.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing