NCT05459298 is a NA clinical trial of 800 IU/day vitamin D supplementation with feedings in the first 28 days after birth in Vitamin D Deficiency, sponsored by The University of Texas Health Science Center, Houston.

Who is sponsoring NCT05459298?

NCT05459298 is sponsored by The University of Texas Health Science Center, Houston.

What condition does NCT05459298 study?

NCT05459298 studies Vitamin D Deficiency.

Is NCT05459298 still recruiting?

NCT05459298 is currently active, enrolled. Last updated 29 September 2025.

Last reviewed 2025-09-29 · How we verify

NCT05459298

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

ViDES Trial (Vitamin D Extra Supplementation)

Active, enrolled NA Last updated 29 September 2025

What this trial tests

NA trial testing Placebo in Vitamin D Deficiency in 180 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

6 September 2022

Primary endpoint
12 August 2025

1 December 2027

Quick facts

Lead sponsor	The University of Texas Health Science Center, Houston
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	other
Enrollment	180
Start date	6 September 2022
Primary completion	12 August 2025
Estimated completion	1 December 2027
Sites	1 location across United States

Drugs / interventions tested

Placebo
800 IU/day vitamin D supplementation with feedings in the first 28 days after birth
Usual Care

Conditions studied

Vitamin D Deficiency — all drugs for Vitamin D Deficiency →

Sponsor

The University of Texas Health Science Center, Houston

Who can join

Adults 24 Hours to 96 Hours, any sex, with Vitamin D Deficiency. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The objective of the study is to compare supplementation with vitamin D at 800 IU/day to usual care for the first 28 days after birth with respect to 25 (OH) vitamin D levels and indicators of likely or plausible effects of vitamin D supplementation on the function or structure of the lung, bones, immune system, and brain in extremely premature (EP) infants who are \<28 weeks gestational age (GA) or \<1000 grams of birth weight (BW). The study results will be analyzed as intention to treat Bayesian analyses (Frequentist analyses will also be performed).

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Randomized controlled trial of enteral vitamin D supplementation (ViDES) in infants <28 weeks gestational age or <1000 g birth weight: study protocol.
Romero-Lopez M, Tyson JE, Naik M, Pedroza C, et al · · 2024 · cited 3× · PMID 38943179 · DOI 10.1186/s13063-024-08274-8
Necrotizing Enterocolitis: What's New and What's Next?
Sha C, Sander WR, Bass K, Hsieh H, et al · · 2025 · cited 1× · PMID 41096926 · DOI 10.3390/ijms26199660
Randomized Controlled Trial of Enteral Vitamin D Supplementation (ViDES) in Infants <28 Weeks Gestational Age or <1000 Grams Birth Weight: Study Protocol
Romero-Lopez M, Tyson JE, Naik M, Pedroza C, et al · · 2024 · DOI 10.21203/rs.3.rs-4049246/v1

Verify or expand the search:

Other trials of 800 IU/day vitamin D supplementation with feedings in the first 28 days after birth

Trials testing the same drug.

NCT05694689 — Randomized Trial of Enteral Vitamin D Supplementation in Infants < 28 Weeks Gestational Age or <1000 Grams Birth Weight · NA · recruiting

Other recruiting trials for Vitamin D Deficiency

Currently open trials in the same condition.

NCT07317830 — Effects of Different Vitamin D3 Formulations in Vitamin D-Deficient Adults · NA · recruiting
NCT07366970 — Is There a Benefit From Addition of Exercise in Diabetic Patients With ED Who Complain Low Vitamin D? · NA · recruiting
NCT07481240 — A Household-Based Dietary Intervention Study of Vitamin D Fortified Bread in Irish Families · NA · recruiting
NCT07006714 — Preoperative Correction of Vitamin D Deficiency in Total Joint Arthroplasty (TJA) · Phase 4 · active not recruiting
NCT07200011 — Effect of Vitamin D on the Clinical and Radiographic of Unsplinted Mandibular Implant Overdentures · active not recruiting

Other The University of Texas Health Science Center, Houston trials

Trials by the same sponsor.

NCT04200729 — Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis: a Multi-cente · Phase 4 · not yet recruiting
NCT07225062 — Improving HIV Prevention and Substance Use Post-Sexual Assault Services · NA · not yet recruiting
NCT07396974 — Increasing Treatment Access in Trauma Exposed Children: Developing an Adapted Step One Intervention (RCT) · NA · not yet recruiting
NCT07170163 — Navigating the Transition to Adulthood: A Dual Language Mobile App for Latino Youth With ASD and Their Families · NA · not yet recruiting
NCT06915441 — Lipid Infusions to Optimize Nutrition Trial · Phase 2 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05459298 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by The University of Texas Health Science Center, Houston
Last refreshed: 29 September 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05459298.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing