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NCT05457322: RELAX
The RELAX Trial: Nonpharmaceutical Intervention for Nocturnal Muscle Cramps
NA trial testing Behavioral intervention one in Cramps in 99 participants. Completed in 14 August 2023.
14 August 2023
Quick facts
| Lead sponsor | University of Michigan |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 99 |
| Start date | 30 August 2022 |
| Primary completion | 14 August 2023 |
| Estimated completion | 14 August 2023 |
| Sites | 6 locations across United States |
Drugs / interventions tested
- Behavioral intervention one
- Behavioral intervention two
Conditions studied
- Cramps — all drugs for Cramps →
- Muscle Cramp — all drugs for Muscle Cramp →
Sponsor
University of Michigan
Who can join
18 and older, any sex, with Cramps or Muscle Cramp. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of the study is to learn about reducing the symptoms and severity of nighttime lower body muscle cramps in patients with and without cirrhosis. Eligible participants will have an initial 7-day practice phase, followed by 28 days of one of two behavioral interventions.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
The RELAX randomized controlled trial: Stretching versus meditation for nocturnal muscle cramps.
Tapper EB, Trivedi H, Simonetto DA, Patwardhan V, et al · · 2024 · cited 5× · PMID 38860445 · DOI 10.1111/liv.16007 -
Muscle cramps in cirrhosis.
Gonzalez JJ, Tapper EB. · · 2024 · cited 4× · PMID 38283307 · DOI 10.1097/cld.0000000000000116
Verify or expand the search:
- PubMed search for NCT05457322
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05457322 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Michigan
- Last refreshed: 11 September 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05457322.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing