Last reviewed · How we verify
NCT05456854
Evaluation of Kisspeptin Stimulated Insulin Secretion With Hyperglycemic Clamp
Phase 1 trial testing Hyperglycemic Clamp in Metabolic Disease. Withdrawn.
1 August 2024
Quick facts
| Lead sponsor | Massachusetts General Hospital |
|---|---|
| Phase | Phase 1 |
| Status | Withdrawn |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | quadruple |
| Primary purpose | other |
| Start date | 3 June 2022 |
| Primary completion | 1 August 2024 |
| Estimated completion | 1 August 2024 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Hyperglycemic Clamp — full drug profile →
- Kisspeptin-10 — full drug profile →
- Placebo
Conditions studied
- Metabolic Disease — all drugs for Metabolic Disease →
Sponsor
Massachusetts General Hospital
Who can join
Adults 18 to 40, female only, with Metabolic Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this study is to understand how exogenous kisspeptin affects metabolism by evaluating responses to an hyperglycemic clamp
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Kisspeptin a potential therapeutic target in treatment of both metabolic and reproductive dysfunction.
Sliwowska JH, Woods NE, Alzahrani AR, Paspali E, et al · · 2024 · cited 9× · PMID 38599822 · DOI 10.1111/1753-0407.13541 -
Kisspeptin Receptor Agonists and Antagonists: Strategies for Discovery and Implications for Human Health and Disease.
Chen X, Yang S, Shaw ND, Xia M. · · 2025 · cited 1× · PMID 40430029 · DOI 10.3390/ijms26104890
Verify or expand the search:
- PubMed search for NCT05456854
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Hyperglycemic Clamp
Trials testing the same drug.
- NCT02844907 — Regulation of Insulin Secretion by the GLP-1 Receptor · Phase 4 · terminated
- NCT03195400 — Pathogenesis of Youth Onset Type 2 Diabetes and Prediabetes · completed
Other recruiting trials for Metabolic Disease
Currently open trials in the same condition.
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- NCT06938386 — Pilot Haskap Metabolite Timing Project · NA · active not recruiting
- NCT06954298 — Molecular Landscape of Complex Lifestyle Modification · NA · active not recruiting
- NCT06717581 — Variation in Drug Interactions in People With HIV (PLWH) Aged 60 Years and Older. · recruiting
- NCT06529965 — Evaluating a Digital Intervention for Alleviating Diabetes-specific Emotional Distress in Adults Living With T2DM · NA · recruiting
Other Massachusetts General Hospital trials
Trials by the same sponsor.
- NCT03585946 — Outcomes in Stevens Johnsons Syndrome and Toxic Epidermal Necrolysis · withdrawn
- NCT07214831 — A Feasibility and Acceptability Study of a Large Language Model-based Chatbot for Brief Alcohol Intervention Among Emerg · NA · not yet recruiting
- NCT06686901 — A Randomized Controlled Trial of a Smartphone Delivered Treatment for Suicidal Thoughts and Behavior · NA · not yet recruiting
- NCT05854212 — Behavioral Economics to Implement Nutrition Ranking in Food Pantries · NA · not yet recruiting
- NCT07323446 — The MIND Study: The MGH/MIT Investigation of NAC on Dysregulation · EARLY_PHASE1 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05456854 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Massachusetts General Hospital
- Last refreshed: 14 August 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05456854.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing