Last reviewed · How we verify
NCT05456113: cannabidiol
Topical Cannabidiol Application and Skin Vascular Reactivity
NA trial testing Cannabidiol in Effect of Drug. Withdrawn.
31 December 2025
Quick facts
| Lead sponsor | Penn State University |
|---|---|
| Phase | NA |
| Status | Withdrawn |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | quadruple |
| Primary purpose | basic science |
| Start date | 1 December 2024 |
| Primary completion | 31 December 2025 |
| Estimated completion | 1 October 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Cannabidiol (CANNABIDIOL) — full drug profile →
Conditions studied
- Effect of Drug — all drugs for Effect of Drug →
Sponsor
Penn State University
Who can join
18 and older, any sex, with Effect of Drug. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Cannabidiol, or CBD, is an over-the-counter "nutraceutical" that is more commonly being used by healthy adults for pain management, recovery from strenuous exercise, and general wellness. However, little research exists on the effects of CBD in otherwise healthy individuals. This study uses iontophoresis, a common technique used in physical therapy, to determine the effectiveness of topical CBD in lessening the reflex increased cutaneous vascular conductance response to stimulation of the skin.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Strategies to Improve Cannabidiol Bioavailability and Drug Delivery.
O'Sullivan SE, Jensen SS, Kolli AR, Nikolajsen GN, et al · · 2024 · cited 23× · PMID 38399459 · DOI 10.3390/ph17020244
Verify or expand the search:
- PubMed search for NCT05456113
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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- NCT06854783 — Safety and Pharmacokinetics of Cannabidiol in Healthy Volunteers · Phase 1 · completed
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Currently open trials in the same condition.
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Other Penn State University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05456113 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Penn State University
- Last refreshed: 17 January 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05456113.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing