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NCT05456061
Effect of ADDE on Tear Interferometry
NA trial testing 3% diquafosol eyedrops in Tear in 152 participants. Completed in 31 January 2022.
1 August 2019
Quick facts
| Lead sponsor | Yonsei University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 152 |
| Start date | 1 August 2018 |
| Primary completion | 1 August 2019 |
| Estimated completion | 31 January 2022 |
| Sites | 1 location across South Korea |
Drugs / interventions tested
- 3% diquafosol eyedrops — full drug profile →
- Silicone punctal plug insertion
Conditions studied
- Tear — all drugs for Tear →
- Dry Eye Syndromes — all drugs for Dry Eye Syndromes →
Sponsor
Yonsei University
Who can join
19 and older, any sex, with Tear or Dry Eye Syndromes. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Importance: Lipid layer thickness (LLT) reflects the lipid components of tear film, but is affected by the mucocutaneous components. This study investigated the therapeutic effect of the treatments for aqueous-deficient dry eye (ADDE) on LLT. Objective: To investigate the effect of ADDE and its treatments on LLT measurements by tear interferometry. Design, Setting, and Participants: This prospective comparative interventional study included 152 eyes from 152 patients with ADDE. Interventions: Participants were classified into four groups: control group (Group 1), 3% diquafosol group (Group 2), punctal plug insertion group (Group 3), and combined treatment group (Group 4). Main Outcomes and Measures: Average LLT (LLTave) was measured using a LipiView® II tear interferometer at baseline and one month after treatments.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05456061
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Related trials
Other recruiting trials for Tear
Currently open trials in the same condition.
- NCT06243497 — Comparison of Cytokines Profile in Aqueous Humor and Tear Before and After UCP Treatment · recruiting
Other Yonsei University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05456061 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Yonsei University
- Last refreshed: 13 July 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05456061.
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