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NCT05453877
Clinical Indicators and Brain Image Data: a Study Based on Kailuan Cohort
trial testing No intervention will be applied. in Brain Diseases in 1,000 participants. Currently enrolling.
1 August 2025
Quick facts
| Lead sponsor | Beijing Friendship Hospital |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 1,000 |
| Start date | 1 August 2022 |
| Primary completion | 1 August 2025 |
| Estimated completion | 1 August 2030 |
| Sites | 2 locations across China |
Drugs / interventions tested
- No intervention will be applied.
Conditions studied
- Brain Diseases — all drugs for Brain Diseases →
- Hypertension — all drugs for Hypertension →
Sponsor
Beijing Friendship Hospital
Who can join
Adults 18 to 90, any sex, with Brain Diseases or Hypertension. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The investigators will analyze the relationship between the medical history, physiological indicators and the cerebral small vessel disease as well as the structural and functional changes of the brain/head and neck organs in a large sample size of subjects (participants), to identify the influencing factors of the occurrence and development of cerebral small vessel disease as well as the structural and functional changes of the brain/head and neck organs, so as to provide objective clues for early intervention of the disease and improve clinical outcomes.
Publications & conference data
8 peer-reviewed publications reference this trial (live from Europe PMC):
-
Association between Body Mass Index and Brain Health in Adults: A 16-Year Population-Based Cohort and Mendelian Randomization Study.
Lv H, Zeng N, Li M, Sun J, et al · · 2024 · cited 29× · PMID 38500551 · DOI 10.34133/hds.0087 -
Protocol for Multi-modality MEdical imaging sTudy bAsed on KaiLuan Study (META-KLS): rationale, design and database building.
Sun J, Hui Y, Li J, Zhao X, et al · · 2023 · cited 20× · PMID 36764715 · DOI 10.1136/bmjopen-2022-067283 -
Association of variability in body size with neuroimaging metrics of brain health: a population-based cohort study.
Sun J, Zeng N, Hui Y, Li J, et al · · 2024 · cited 17× · PMID 38328337 · DOI 10.1016/j.lanwpc.2024.101015 -
Clinical information prompt-driven retinal fundus image for brain health evaluation.
Tong N, Hui Y, Gou SP, Chen LX, et al · · 2025 · cited 8× · PMID 40770361 · DOI 10.1186/s40779-025-00630-2 -
Ambient air pollution exposure in relation to cerebral small vessel disease in Chinese population: A cranial magnetic resonance imaging-based study.
Ma Y, Hui Y, Tang L, Wang J, et al · · 2025 · cited 5× · PMID 39925481 · DOI 10.1016/j.eehl.2024.10.004 -
Retinal Vascular Morphology Reflects and Predicts Cerebral Small Vessel Disease: Evidences from Eye-Brain Imaging Analysis.
Wu N, Xu M, Chen S, Wu S, et al · · 2025 · cited 4× · PMID 40052159 · DOI 10.34133/research.0633 -
Serum uric acid is associated with midbrain enlarged perivascular spaces: Results from Multi-modality Medical imaging sTudy bAsed on KaiLuan Study (META-KLS).
Zhang T, Lv H, Zhao X, Zeng N, et al · · 2024 · cited 4× · PMID 38580007 · DOI 10.1016/j.pnpbp.2024.111000 -
Association of long-term exposure to lower low-density lipoprotein cholesterol with neuroimaging metrics: A population-based cohort study.
Sun J, Hui Y, Li J, Zhao X, et al · · 2026 · PMID 42230333 · DOI 10.1097/cm9.0000000000004105
Verify or expand the search:
- PubMed search for NCT05453877
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05453877 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Beijing Friendship Hospital
- Last refreshed: 31 October 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05453877.
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