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NCT05449821
Investigation of Asprosin a Novel Adipokine in Periodontitis
trial testing Serum and salivary samples will be collected. Asprosin levels will be determined by biochemical analysis in Periodontitis in 65 participants. Completed in 1 December 2022.
1 November 2022
Quick facts
| Lead sponsor | Ataturk University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 65 |
| Start date | 1 January 2022 |
| Primary completion | 1 November 2022 |
| Estimated completion | 1 December 2022 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Serum and salivary samples will be collected. Asprosin levels will be determined by biochemical analysis
Conditions studied
- Periodontitis — all drugs for Periodontitis →
- Obesity — all drugs for Obesity →
- Diabetes Mellitus — all drugs for Diabetes Mellitus →
Sponsor
Ataturk University
Who can join
Adults 18 to 60, any sex, with Periodontitis or Obesity. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Asprosin, a recently discovered glucogenic adipokine, is mainly synthesized by white adipose tissue and released during fasting. Appetite, glucose metabolism, insulin resistance, cell apoptosis, etc. asprosin is associated with diseases such as diabetes, obesity, polycystic ovary syndrome, and cardiovascular diseases. Periodontal tissue may act as a source of endocrine-like inflammatory mediators (such as TNF-α, IL-6 and IL-1) that are important in periodontal inflammation and can affect glucose and lipid metabolism. Production of TNF-α and IL-6 in adipose tissues strengthens the relationship between obesity, T2DM and periodontitis.we postulated that asprosin may be candidate for explaining the triangular relationship among obesity, T2DM, and periodontal disease.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Salivary and serum asprosin hormone levels in the 2018 EFP/AAP classification of periodontitis stages and body mass index status: a case-control study.
Gül SNS, Eminoğlu DÖ, Laloğlu E, Aydın T, et al · · 2024 · cited 3× · PMID 38217801 · DOI 10.1007/s00784-024-05494-9
Verify or expand the search:
- PubMed search for NCT05449821
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05449821 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ataturk University
- Last refreshed: 1 February 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05449821.
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