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NCT05449327
Xarelto for Thromboprophylaxis After Total Hip and Total Knee Arthroplasty
NA trial testing Rivaroxaban 10 MG in Venous Thromboembolism in 178 participants. Status unknown.
21 December 2025
Quick facts
| Lead sponsor | Chiayi Christian Hospital |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 178 |
| Start date | 1 February 2023 |
| Primary completion | 21 December 2025 |
| Estimated completion | 21 December 2025 |
| Sites | 1 location across Taiwan |
Drugs / interventions tested
- Rivaroxaban 10 MG — full drug profile →
Conditions studied
- Venous Thromboembolism — all drugs for Venous Thromboembolism →
- Arthroplasty — all drugs for Arthroplasty →
Sponsor
Chiayi Christian Hospital
Who can join
20 and older, any sex, with Venous Thromboembolism or Arthroplasty. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Venous thromboembolism is a serious complication after total hip replacement (THR) and total knee replacement (TKR). Previous studies have reported the incidence of both asymptomatic and symptomatic deep vein thrombosis (DVT) after TKR were higher in Taiwan than other countries in Asia. Therefore, the usage of prophylactic antithrombotics should be considered. The efficacy and safety of Xarelto (Rivaroxaban) for preventing venous thromboembolism has been proved. However, there is a lack of study using prospective design to evaluate the efficacy and safety of Xarelto after THR and TKR for Taiwanese. In this study, the investigators use a randomized controlled trial design comparing the incidence of DVT, pulmonary embolism, and complications between intervention and control groups.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05449327
- Europe PMC full search
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Currently open trials in the same condition.
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Other Chiayi Christian Hospital trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05449327 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Chiayi Christian Hospital
- Last refreshed: 3 October 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05449327.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing