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NCT05449002
Digital Single Session Intervention for Youth Mental Health
NA trial testing Practicing the Opposite (PTO) in Anxiety in 226 participants. Currently enrolling.
31 May 2027
Quick facts
| Lead sponsor | Harvard University |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 226 |
| Start date | 5 September 2022 |
| Primary completion | 31 May 2027 |
| Estimated completion | 30 September 2027 |
| Sites | 5 locations across United States |
Drugs / interventions tested
- Practicing the Opposite (PTO)
- Usual Clinical Care
Conditions studied
- Anxiety — all drugs for Anxiety →
- Depression — all drugs for Depression →
- Conduct Disorder — all drugs for Conduct Disorder →
- Stress — all drugs for Stress →
Sponsor
Harvard University
Who can join
Adults 9 to 17, any sex, with Anxiety or Depression. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of this study is to test the effectiveness of a single-session, digital intervention teaching the principle of practicing the opposite, when administered to youths on the waitlist for psychotherapy, with usual waitlist procedures as a control condition.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05449002
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Harvard University trials
Trials by the same sponsor.
- NCT07316647 — Using Conversational AI to Teach Growth Mindset Skills to Youths in India · NA · completed
- NCT06114862 — Brief Interventions on Social Media to Reduce Suicide Risk (Intervention 2) · NA · withdrawn
- NCT07394465 — First Tones: Artistic Communal Practices for 4 and 5 Year Old Children · NA · completed
- NCT06217705 — Testing the Effects of Project Calm in Ukrainian Schools · NA · completed
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05449002 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Harvard University
- Last refreshed: 15 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05449002.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing