Last reviewed · How we verify
NCT05448846: ECOOL
Exercise Program for Colorectal Older Patients
NA trial testing Enhanced Recovery After Surgery in Colorectal Neoplasms in 252 participants. Participants enrolled and being followed up; not accepting new ones.
30 June 2026
Quick facts
| Lead sponsor | Hospital General Universitario Gregorio Marañon |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | supportive care |
| Enrollment | 252 |
| Start date | 8 April 2022 |
| Primary completion | 30 June 2026 |
| Estimated completion | 30 June 2026 |
| Sites | 1 location across Spain |
Drugs / interventions tested
- Enhanced Recovery After Surgery — full drug profile →
- Home-based multicomponent exercise program (EXE)
Conditions studied
- Colorectal Neoplasms — all drugs for Colorectal Neoplasms →
- Aged — all drugs for Aged →
Sponsor
Hospital General Universitario Gregorio Marañon
Who can join
75 and older, any sex, with Colorectal Neoplasms or Aged. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The Exercise for COlorectal OLder patients (ECOOL program) is randomized controlled trial to assess the effects of an exercise program on physical function and health-related quality of life of patients 75 years and older with colorectal cancer undergoing surgery. ECOOL is a multicomponent home-based exercise intervention focused on the development of strength, balance, gait ability and inspiratory muscle function of older patients who receive weekly telephone follow-up from cancer diagnosis to 3 months after surgery. The investigators expect that ECOOL program will improve physical function and health-related quality of life of older patients 3 months after surgery and to maintain these benefits up to 6 months after surgery compared with the control group receiving usual care.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Exercise effects on functional capacity and quality of life in older patients with colorectal cancer: study protocol for the ECOOL randomized controlled trial.
Macías-Valle A, Rodríguez-López C, González-Senac NM, Mayordomo-Cava J, et al · · 2023 · cited 7× · PMID 37211611 · DOI 10.1186/s12877-023-04026-6
Verify or expand the search:
- PubMed search for NCT05448846
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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- NCT04505111 — Prehabilitation Plus ERAS vs ERAS in Gynecological Surgery · NA · withdrawn
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Currently open trials in the same condition.
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Other Hospital General Universitario Gregorio Marañon trials
Trials by the same sponsor.
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- NCT06998862 — Colchicine in Chronic Kidney Disease Patients · Phase 3 · recruiting
- NCT05853081 — FODEPOC Study: Fat-free Mass Index in Copd · unknown
- NCT06052436 — Cell Therapy With Treg Cells Obtained From Thymic Tissue (thyTreg) to Control the Immune Hyperactivation Associated With · Phase 1, PHASE2 · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05448846 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospital General Universitario Gregorio Marañon
- Last refreshed: 8 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05448846.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing