NCT05447026

The Effect of Adjunctive Therapies in Regenerative Treatment of Stage III Grade C Periodontitis

Completed NA Last updated 30 August 2023

What this trial tests

NA trial testing Control group in Periodontitis in 48 participants. Completed in 15 September 2022.

Timeline

1 January 2018

Primary endpoint
10 February 2022

15 September 2022

Quick facts

Lead sponsor	Gazi University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	48
Start date	1 January 2018
Primary completion	10 February 2022
Estimated completion	15 September 2022
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

• Control group — full drug profile →
• Antimicrobial photodynamic therapy (aPDT) group
• LED photobiomodulation group
• Topical ozone group

Conditions studied

• Periodontitis — all drugs for Periodontitis →
• Lasers — all drugs for Lasers →
• Ozone — all drugs for Ozone →
• Wound Healing — all drugs for Wound Healing →

Sponsor

Gazi University

Who can join

Adults 18 to 35, any sex, with Periodontitis or Lasers. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Anti-infective procedures play a very important role in the success of regenerative surgical treatment of aggressive periodontitis, Grade C periodontitis, which shows the newly named molar-incisor pattern according to the 2017 World Workshop Classification of Periodontal Diseases. In the present study, it was aimed to analyze the effects of photodynamic, photobiomodulation, and ozone therapy applications on periodontal healing, both clinically and immunologically, in addition to the surgical regenerative treatment of aggressive periodontitis. Forty adult individuals diagnosed with aggressive periodontitis who applied to Gazi University Faculty of Dentistry Department of Periodontology for the treatment of periodontal disease were included in the study. In addition to the regenerative surgical treatment using cortico-cancellous particle allograft and a resorbable collagen membrane in randomly determined areas with multiple intraosseous defects, topical ozone, antimicrobial photodynamic, and light-emitting diode (LED) photobiomodulation treatments were applied. Periodontal clinical parameters \[plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing pocket depths (PPD), clinical attachment level (CAL), gingival recession (GR), and width of keratinized gingival (WKG)\] were examined and patient-centered postoperative evaluations, and early wound healing index (EHI) assessments were performed for 2 weeks after the operation. In addition, gingival crevicular fluid (GCF) samples from patients to determine the total amount and concentration of vascular endothelial growth factor (VEGF), interleukin -6 (IL-6), Runt-related transcription factor 2 (RunX2), NEL-like 1 (Nell-1), Osterix and samples were quantified by Quantitative Real-Time PCR. The repeated measures ANOVA model was used for the analysis of variables in which both group and time measurements were taken.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. The adjunctive use of antimicrobial photodynamic therapy, light-emitting-diode photobiomodulation and ozone therapy in regenerative treatment of stage III/IV grade C periodontitis: a randomized controlled clinical trial.
   Cetiner DO, Isler SC, Ilikci-Sagkan R, Sengul J, et al · · 2024 · cited 8× · PMID 38992200 · DOI 10.1007/s00784-024-05794-0
2. Reactive oxygen species in health and disease.
   Ren Y, Li J, Dai X. · · 2026 · PMID 41824175 · DOI 10.1186/s43556-026-00419-2