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NCT05446584: PATH
Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History
Phase 2 trial testing High Definition Transcranial Direct Current Stimulation in Mild Cognitive Impairment in 75 participants. Currently enrolling.
1 May 2027
Quick facts
| Lead sponsor | University of Texas Southwestern Medical Center |
|---|---|
| Phase | Phase 2 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | diagnostic |
| Enrollment | 75 |
| Start date | 20 April 2023 |
| Primary completion | 1 May 2027 |
| Estimated completion | 31 May 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- High Definition Transcranial Direct Current Stimulation
Conditions studied
- Mild Cognitive Impairment — all drugs for Mild Cognitive Impairment →
- Amnestic Mild Cognitive Disorder — all drugs for Amnestic Mild Cognitive Disorder →
- Amnestic Mild Cognitive Impairment — all drugs for Amnestic Mild Cognitive Impairment →
- Mild Traumatic Brain Injury — all drugs for Mild Traumatic Brain Injury →
Sponsor
University of Texas Southwestern Medical Center
Who can join
55 and older, any sex, with Mild Cognitive Impairment or Amnestic Mild Cognitive Disorder. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study will probe if the biological changes in amnestic mild cognitive impairment (aMCI) are related to a history of mild traumatic brain injury (mTBI) using high definition transcranial direct current stimulation (HD-tDCS) and blood-derived biomarker tools. Participants who Do as well as those who Do Not have a history of mTBI will be enrolled in the study.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05446584
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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Other recruiting trials for Mild Cognitive Impairment
Currently open trials in the same condition.
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Other University of Texas Southwestern Medical Center trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05446584 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Texas Southwestern Medical Center
- Last refreshed: 4 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05446584.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing