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NCT05445349: CHOICE
Breathing Parameter Measurements for Lung Deposition Simulation
trial testing Emptied dry powder inhalers (DPI) used in routine asthma and COPD therapy in Asthma in 163 participants. Completed in 30 June 2025.
30 June 2024
Quick facts
| Lead sponsor | Medisol Development Kft. |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 163 |
| Start date | 1 September 2022 |
| Primary completion | 30 June 2024 |
| Estimated completion | 30 June 2025 |
| Sites | 3 locations across Hungary |
Drugs / interventions tested
- Emptied dry powder inhalers (DPI) used in routine asthma and COPD therapy
Conditions studied
Sponsor
Medisol Development Kft.
Who can join
18 and older, any sex, with Asthma or COPD. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study aims to simulate the deposition of aerosol drugs within the airways of asthma and COPD patients based on realistic breathing patterns measured at different pulmonology centers. Further goal of the study is to find correlations between the amount of drug depositing in the lungs and the measured breathing parameters, as well as disease status and demographic data. The results of the study will be part of a major objective targeting the optimization and personalization of aerosol drug therapy.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
The effect of exhalation before the inhalation of dry powder aerosol drugs on the breathing parameters, emitted doses and aerosol size distributions.
Farkas Á, Tomisa G, Kugler S, Nagy A, et al · · 2023 · cited 4× · PMID 36824288 · DOI 10.1016/j.ijpx.2023.100167 -
The effect of lung emptying before the inhalation of aerosol drugs on drug deposition in the respiratory system.
Farkas Á, Tomisa G, Szénási G, Füri P, et al · · 2023 · cited 2× · PMID 37405278 · DOI 10.1016/j.ijpx.2023.100192
Verify or expand the search:
- PubMed search for NCT05445349
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05445349 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Medisol Development Kft.
- Last refreshed: 28 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05445349.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing