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NCT05443061
Subcutaneous Nitroglycerin to Prevent Radial Artery Occlusion in Children
NA trial testing Nitroglycerin in Arterial Line in 200 participants. Completed in 24 March 2025.
24 March 2025
Quick facts
| Lead sponsor | Seoul National University Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | prevention |
| Enrollment | 200 |
| Start date | 8 September 2022 |
| Primary completion | 24 March 2025 |
| Estimated completion | 24 March 2025 |
| Sites | 1 location across South Korea |
Drugs / interventions tested
- Nitroglycerin (glyceryl trinitrate) — full drug profile →
- Normal saline
Conditions studied
- Arterial Line — all drugs for Arterial Line →
- Ischemia — all drugs for Ischemia →
Sponsor
Seoul National University Hospital
Who can join
Under 36 Months, any sex, with Arterial Line or Ischemia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The primary objective of the study is to evaluate the vasodilative effect of subcutaneous nitroglycerin to prevent radial arterial occlusion(RAO) after removal of the radial arterial catheter in pediatric patients. The hypothesis of this study is that subcutaneous nitroglycerin will decrease the incidence of radial arterial occlusion after radial arterial catheter removal in pediatric patients by increasing the radial artery size. This is a single-center, double-blind, randomized, placebo-controlled study comparing the effect of subcutaneous nitroglycerin and saline on radial artery cannulation and catheter removal in pediatric patients. Prior to the procedure, each patient will be randomized into either the control arm, saline, or the study arm, nitroglycerin.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Subcutaneous Nitroglycerin to Prevent Radial Artery Occlusion in Pediatric Patients: A Randomized Clinical Trial.
Park JB, Ji SH, Kim EH, Lee JH, et al · · 2025 · PMID 41051743 · DOI 10.1001/jamapediatrics.2025.3652
Verify or expand the search:
- PubMed search for NCT05443061
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Seoul National University Hospital trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05443061 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Seoul National University Hospital
- Last refreshed: 29 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05443061.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing