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NCT05442021
Direct Current Neuromuscular Electrical Stimulation for Treatment of Peripheral Neuropathy
NA trial testing Neubie Direct Current Electrical Stimulation Device in Neuropathy in 148 participants. Completed in 20 May 2023.
20 May 2023
Quick facts
| Lead sponsor | NeuFit - Neurological Fitness and Education |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 148 |
| Start date | 1 August 2022 |
| Primary completion | 20 May 2023 |
| Estimated completion | 20 May 2023 |
| Sites | 11 locations across United States |
Drugs / interventions tested
- Neubie Direct Current Electrical Stimulation Device
- TENS
Conditions studied
- Neuropathy — all drugs for Neuropathy →
Sponsor
NeuFit - Neurological Fitness and Education
Who can join
18 and older, any sex, with Neuropathy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study will compare two methods of electrical stimulation (alternating current and direct current) as an adjunctive therapy to treating peripheral neuropathy. Both types of electrical stimulation have been used in clinical practice for physical therapy, however direct current stimulation is much less common and there is less known about their impact on physical therapy outcomes. The aim of this project is to show the efficacy of a novel device, the Neubie direct current device, compared to traditional TENS unit, in clinical physical therapy treatment of neuropathy. Outcomes measured will include three methods of two-point discrimination, vibration sense, pain, and score on the modified Toronto Clinical Neuropathy scale.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
An Open-Label Comparative Study of the Impact of Two Types of Electrical Stimulation (Direct Current Neuromuscular Electrical Stimulation and Transcutaneous Electrical Stimulation) on Physical Therapy Treatment of Diabetic Peripheral Neuropathy.
Kostopoulos D, Rizopoulos K, McGilvrey J, Hauskey J, et al · · 2025 · cited 3× · PMID 39949402 · DOI 10.1155/jdr/9970124
Verify or expand the search:
- PubMed search for NCT05442021
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Neubie Direct Current Electrical Stimulation Device
Trials testing the same drug.
- NCT06421558 — Impact of Direct Current Electrical Stimulation on Treatment of Lumbosacral Radiculopathy · NA · recruiting
Other recruiting trials for Neuropathy
Currently open trials in the same condition.
- NCT07390279 — Efficacy of Transcutaneous Pulsed Radiofrequency in Postherpetic Neuralgia · recruiting
- NCT07390617 — A Study of Neuropathy Caused by Enfortumab Vedotin in People With Urothelial Carcinoma · recruiting
- NCT06807294 — Feasibility Testing of a Tai Chi Program for Chemotherapy-Induced Peripheral Neuropathy Treatment (TCT) · NA · recruiting
- NCT06837181 — Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM) · recruiting
- NCT06912646 — Clinical Efficacy of the Erchonia EVRL for Providing Temporary Relief of Idiopathic Peripheral Neuropathy Foot Pain · NA · recruiting
Other NeuFit - Neurological Fitness and Education trials
Trials by the same sponsor.
- NCT06421558 — Impact of Direct Current Electrical Stimulation on Treatment of Lumbosacral Radiculopathy · NA · recruiting
- NCT05229692 — Effect of Neuromuscular Electrical Stimulation on the Post-Operative Abdominoplasty Patient. · NA · withdrawn
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05442021 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by NeuFit - Neurological Fitness and Education
- Last refreshed: 25 May 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05442021.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing