NCT05441839 (UK HFpEF) is a clinical trial in Heart Failure With Preserved Ejection Fraction (HFpEF), sponsored by Manchester University NHS Foundation Trust.

Who is sponsoring NCT05441839?

NCT05441839 is sponsored by Manchester University NHS Foundation Trust.

What condition does NCT05441839 study?

NCT05441839 studies Heart Failure With Preserved Ejection Fraction (HFpEF).

Is NCT05441839 still recruiting?

NCT05441839 is currently recruiting now. Last updated 6 May 2025.

Last reviewed 2025-05-06 · How we verify

NCT05441839: UK HFpEF

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

UK Heart Failure With Preserved Ejection Fraction

Recruiting now Last updated 6 May 2025

What this trial tests

trial in Heart Failure With Preserved Ejection Fraction (HFpEF) in 10,000 participants. Currently enrolling.

Timeline

7 October 2022

Primary endpoint
1 June 2037

1 June 2037

Quick facts

Lead sponsor	Manchester University NHS Foundation Trust
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	10,000
Start date	7 October 2022
Primary completion	1 June 2037
Estimated completion	1 June 2037
Sites	26 locations across United Kingdom

Conditions studied

Heart Failure With Preserved Ejection Fraction (HFpEF) — all drugs for Heart Failure With Preserved Ejection Fraction (HFpEF) →

Sponsor

Manchester University NHS Foundation Trust

Who can join

18 and older, any sex, with Heart Failure With Preserved Ejection Fraction (HFpEF). Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Heart failure occurs when the heart is no longer able to pump blood around the body properly. It can cause breathlessness, swollen feet and ankles, and tiredness. In about half of patients with heart failure, one measure of the heart's pumping function, called the 'ejection fraction', is normal. This type of heart failure is called heart failure with preserved ejection fraction, or HFpEF. HFpEF remains poorly understood. It is not clear why some people develop HFpEF, or what determines the severity of the condition. Treatment options may be limited. UK HFpEF is a study that aims to gain a better understanding of why people develop HFpEF, develop better tests to diagnosis it, identify and test new treatments, and follow the health of the people taking part over many years.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Rationale and design of the United Kingdom Heart Failure with Preserved Ejection Fraction Registry.
UK HFpEF Collaborative Group. · · 2024 · cited 8× · PMID 37827557 · DOI 10.1136/heartjnl-2023-323049
Phenogrouping heart failure with preserved or mildly reduced ejection fraction using electronic health record data.
Soltani F, Jenkins DA, Kaura A, Bradley J, et al · · 2024 · cited 3× · PMID 38969974 · DOI 10.1186/s12872-024-03987-9
An integrated Biobank in the Swedish Heart Failure Registry-clinomics, proteomics, transcriptomics and genomics.
Hage C, Andersson T, Christersson C, Linde C, et al · · 2026 · PMID 41961636 · DOI 10.1093/eschf/xvag092

Verify or expand the search:

Other recruiting trials for Heart Failure With Preserved Ejection Fraction (HFpEF)

Currently open trials in the same condition.

NCT06560762 — Study in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF) · Phase 1 · recruiting
NCT04822649 — Exercise Capacity According to Coronary Microvascular Dysfunction and Body Composition · NA · recruiting
NCT03876223 — Women's Ischemia Syndrome Evaluation (WISE) Pre-HFpEF · recruiting

Other Manchester University NHS Foundation Trust trials

Trials by the same sponsor.

NCT07057284 — DENTOFACIAL-PBT Stage 2 - Feasibility Study · enrolling by invitation
NCT06972238 — Glucose Levels in Acute Pancreatitis and the Impact of Insulin Depletion and Bacterial Endotoxaemia · not yet recruiting
NCT06681545 — Exploring the Lived Experience of Young Adults With Severe Asthma · recruiting
NCT07049263 — Disparities In Access to the Northwest Ambulance Service During Pregnancy, Birth and Postpartum Period and Its Associati · active not recruiting
NCT06561334 — Spasmodic Dysphonia Interviews · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05441839 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Manchester University NHS Foundation Trust
Last refreshed: 6 May 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05441839.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing