NCT05436392 (DROP-Benzo) is a NA clinical trial of Peer Comparison Feedback in Surgery, sponsored by University of Pennsylvania.

Who is sponsoring NCT05436392?

NCT05436392 is sponsored by University of Pennsylvania.

What drugs are being tested in NCT05436392?

Interventions in NCT05436392: Peer Comparison Feedback, Patient Informational Letter.

What condition does NCT05436392 study?

NCT05436392 studies Surgery, Aging.

Is NCT05436392 still recruiting?

NCT05436392 is currently completed. Last updated 18 January 2024.

Last reviewed 2024-01-18 · How we verify

NCT05436392: DROP-Benzo

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

De-adopting Routine Preoperative Benzodiazepines for Older Surgical Patients

Completed NA Last updated 18 January 2024

What this trial tests

NA trial testing Peer Comparison Feedback in Surgery in 517,611 participants. Completed in 31 December 2023.

Timeline

8 August 2022

Primary endpoint
30 June 2023

31 December 2023

Quick facts

Lead sponsor	University of Pennsylvania
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	factorial
Masking	none
Primary purpose	health services research
Enrollment	517,611
Start date	8 August 2022
Primary completion	30 June 2023
Estimated completion	31 December 2023
Sites	1 location across United States

Drugs / interventions tested

Peer Comparison Feedback
Patient Informational Letter

Conditions studied

Surgery — all drugs for Surgery →
Aging — all drugs for Aging →

Sponsor

University of Pennsylvania

Who can join

65 and older, any sex, with Surgery or Aging. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Over 21 million surgical procedures take place among adults aged 65 and older in the US each year, and most older surgical patients in the US now receive benzodiazepines (e.g., midazolam, lorazepam) during anesthesia care. This occurs despite recommendations to avoid these medications in older patients due to associated medical risks and lack of demonstrated benefit. In other words, routine benzodiazepine administration to older surgical patients is likely to represent low-value care that is a suitable target for de-adoption. In this study, we will evaluate a United States Anesthesia Partners (USAP, Dallas, TX) quality improvement initiative using peer comparison feedback to clinicians and/or mailed informational letters to patients as strategies to encourage physician de-adoption of routine preoperative benzodiazepine administration to older surgical patients. In partnership with USAP, this study will be conducted using randomization to evaluate its effect.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Strategies to Limit Benzodiazepine Use in Anesthesia for Older Adults: A Randomized Clinical Trial.
Neuman MD, Feng R, Shukla AS, Han X, et al · · 2024 · PMID 39480422 · DOI 10.1001/jamanetworkopen.2024.42207

Verify or expand the search:

Other recruiting trials for Surgery

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NCT07342751 — The Effect of Listening to Music During Mobilization on Pain and Fear in Children Undergoing Abdominal Surgery · NA · active not recruiting

Other University of Pennsylvania trials

Trials by the same sponsor.

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NCT06645769 — Na-Phenylbutyrate VAscular Trial · EARLY_PHASE1 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05436392 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Pennsylvania
Last refreshed: 18 January 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05436392.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing