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NCT05435092: CAT
Clinical Correlation of TKA Alignment and Native Knee Anatomy
trial testing 3D-reconstruction CT in Total Knee Arthroplasty (TKA) in 75 participants. Participants enrolled and being followed up; not accepting new ones.
30 October 2026
Quick facts
| Lead sponsor | University Hospital, Basel, Switzerland |
|---|---|
| Status | Active, enrolled |
| Study type | OBSERVATIONAL |
| Enrollment | 75 |
| Start date | 1 April 2022 |
| Primary completion | 30 October 2026 |
| Estimated completion | 30 October 2026 |
| Sites | 1 location across Switzerland |
Drugs / interventions tested
- 3D-reconstruction CT
Conditions studied
- Total Knee Arthroplasty (TKA) — all drugs for Total Knee Arthroplasty (TKA) →
Sponsor
University Hospital, Basel, Switzerland
Who can join
18 and older, any sex, with Total Knee Arthroplasty (TKA). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Total knee arthroplasty (TKA) is still considered the treatment of choice for painful osteoarthritis. In the last decades neutral mechanical knee alignment in the coronal plane has been considered the gold standard. However, the optimal TKA alignment is still debated. Today, component rotation measurements on three-dimensional (3D) reconstructed computed tomography (CT) images are considered the gold standard for assessing native preoperative alignment and TKA component position. In this study pre-and postoperative radiographic measurements, functional scores, and biomechanical parameters of patients with knee osteoarthritis will be assessed with the aim to investigate the relationship between deviations of TKA alignment from native preoperative alignment and clinical, functional and biomechanical alignment.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05435092
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other University Hospital, Basel, Switzerland trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05435092 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Basel, Switzerland
- Last refreshed: 31 January 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05435092.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing