NCT05432570

Use of Muscle Relaxants in Parotidectomy Operation With Neuromonitoring

Completed NA Last updated 14 March 2023

What this trial tests

NA trial testing Group A - Muscle Relaxants Used in Intubation; Difficult or Failed in 40 participants. Completed in 30 December 2022.

Timeline

30 June 2022

Primary endpoint
30 October 2022

30 December 2022

Quick facts

Lead sponsor	Bezmialem Vakif University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	screening
Enrollment	40
Start date	30 June 2022
Primary completion	30 October 2022
Estimated completion	30 December 2022
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

• Group A - Muscle Relaxants Used
• Group B - No Muscle Relaxants

Conditions studied

• Intubation; Difficult or Failed — all drugs for Intubation; Difficult or Failed →
• Muscle Relaxation — all drugs for Muscle Relaxation →
• Anesthesia Intubation Complication — all drugs for Anesthesia Intubation Complication →
• Airway Complication of Anesthesia — all drugs for Airway Complication of Anesthesia →

Sponsor

Bezmialem Vakif University

Who can join

Adults 18 to 65, any sex, with Intubation; Difficult or Failed or Muscle Relaxation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Neuromuscular blockers provide muscle relaxation by blocking the electrical conduction to motor nerves and facilitate endotracheal tube placement while relaxing the whole body for surgical comfort during general anesthesia. Parotid surgery is a procedure performed by ear, nose and throat physicians, and as a complication during this procedure, permanent facial paralysis may develop due to damage to the facial nerve. Intraoperative nerve monitoring is frequently used to avoid this complication. The application of local anesthetic to the vocal cords and into the trachea has been tried and found useful for induction of anesthesia without the use of neuromuscular blockers. In studies conducted with this technique, a standard local anesthetic dose was not specified and local anesthetics were generally administered alone and in high doses. It is expected that anesthesia induction and intubation without the use of muscle relaxants will not affect the comfort of the patient and the procedure, but will increase the surgical time and surgical satisfaction.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.