NCT05431920 is a NA clinical trial of Vitamin D₃ (25-hydroxy vitamin D) in Non-allergic Asthma, sponsored by Hospital Infantil de Mexico Federico Gomez.

Who is sponsoring NCT05431920?

NCT05431920 is sponsored by Hospital Infantil de Mexico Federico Gomez.

What drugs are being tested in NCT05431920?

Interventions in NCT05431920: Vitamin D₃ (25-hydroxy vitamin D), Vitamin D₃ (25-hydroxy vitamin D).

What condition does NCT05431920 study?

NCT05431920 studies Non-allergic Asthma, Obesity, Vitamin D Deficiency.

Is NCT05431920 still recruiting?

NCT05431920 is currently active, enrolled. Last updated 15 September 2025.

Last reviewed 2025-09-15 · How we verify

NCT05431920

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effects of Vitamin D Supplementation in Adolescents With Asthma, Obesity and Vitamin D Deficiency.

Active, enrolled NA Last updated 15 September 2025

What this trial tests

NA trial testing Vitamin D₃ (25-hydroxy vitamin D) in Non-allergic Asthma in 264 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

1 October 2022

Primary endpoint
1 December 2025

31 December 2026

Quick facts

Lead sponsor	Hospital Infantil de Mexico Federico Gomez
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	264
Start date	1 October 2022
Primary completion	1 December 2025
Estimated completion	31 December 2026
Sites	1 location across Mexico

Drugs / interventions tested

Vitamin D₃ (25-hydroxy vitamin D)
Vitamin D₃ (25-hydroxy vitamin D)

Conditions studied

Non-allergic Asthma — all drugs for Non-allergic Asthma →
Obesity — all drugs for Obesity →
Vitamin D Deficiency — all drugs for Vitamin D Deficiency →

Sponsor

Hospital Infantil de Mexico Federico Gomez

Who can join

Adults 12 to 17, any sex, with Non-allergic Asthma or Obesity. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Obesity has been associated with a specific non-allergic asthma phenotype and to a deficiency of vitamin D in at least 90% of the pediatric population. Adolescents with non-allergic asthma and vitamin D deficiency have up to six times the risk \[OR: 6.2 (IC95% 2.0-21.6), p=0.002\] of having a severe asthmatic crisis and do not respond adequately to inhaled steroid treatment. To evaluate the effect of oral vitamin D3 supplementation with 50,000 IU single dose and 4,000 IU daily vs 2,000 IU daily on the Asthma Control Questionnaire score, number and incidence of asthmatic crisis, lung function, and Th17 inflammatory biomarkers in adolescents with asthma associated to obesity and vitamin D insufficiency/deficiency for three months.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Management of the pediatric patient with asthma and obesity.
Averill SH, Forno E. · · 2024 · cited 10× · PMID 37827386 · DOI 10.1016/j.anai.2023.10.001
Gaps and Future Directions in Clinical Research on Obesity-Related Asthma.
Hudler AC, Díaz IRR, Sharma S, Holguin F. · · 2023 · cited 5× · PMID 37330948 · DOI 10.1007/s41030-023-00230-2
Obesity: Next game changer of allergic airway diseases?
Li W, Marx N, Yang Q, Fang D, et al · · 2025 · cited 2× · PMID 40329860 · DOI 10.1002/ctm2.70316

Verify or expand the search:

Other Hospital Infantil de Mexico Federico Gomez trials

Trials by the same sponsor.

NCT07376252 — Use of a Mobile Application by Parents to Prevent Obesity in Their Children Apply for Your Health · NA · enrolling by invitation
NCT05276960 — Efficacy of Intensive Cholecalciferol Monitoring and Supplementation on Serum vitD Levels in Pediatric Patients With CF · Phase 4 · completed
NCT03577600 — Compassionate Treatment in Children With Brain Tumors With the Cytotron® · NA · withdrawn
NCT03951558 — Comparison of the Impact of Diet vs Thiazide in BMD in Children With Idiopathic Hypercalciuria · NA · unknown
NCT06174454 — Clinical Efficacy of Respiratory Pediatric Physiotherapy on a Child With Hospital Treated Pneumonia · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05431920 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Hospital Infantil de Mexico Federico Gomez
Last refreshed: 15 September 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05431920.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing