NCT05428891

Image-guided Pleural Biopsy or Medical Thoracosocopy in Diagnosis of Pleural Disease

Completed NA Last updated 11 September 2023

What this trial tests

NA trial testing Abrams' needle pleural biopsy (IG-ANPB) versus medical thoracoscopy in the diagnosis of pleural diseases. in Diagnosis of Pleural Diseases in 228 participants. Completed in 1 May 2022.

Timeline

30 April 2017

Primary endpoint
27 February 2022

1 May 2022

Quick facts

Lead sponsor	Eskisehir Osmangazi University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	diagnostic
Enrollment	228
Start date	30 April 2017
Primary completion	27 February 2022
Estimated completion	1 May 2022
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

• Abrams' needle pleural biopsy (IG-ANPB) versus medical thoracoscopy in the diagnosis of pleural diseases.

Conditions studied

• Diagnosis of Pleural Diseases — all drugs for Diagnosis of Pleural Diseases →

Sponsor

Eskisehir Osmangazi University

Who can join

Adults 18 to 90, any sex, with Diagnosis of Pleural Diseases. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Pleural diseases can occur due to numerous pathological conditions. The increasing prevalence of etiologic causes and aging population worldwide will make pleural diseases a growing problem in the coming years. As a result of this increase, the need for diagnostic investigations is also increasing. In recent years, the use of image-guided needle biopsies under ultrasound (US) or computed tomography (CT) and the increasing use of medical thoracoscopy (MT) have significantly increased the accuracy of diagnosis of pleural disease. There is not yet a generally accepted algorithm for invasive diagnosis of pleural disease, widely used in clinics, that determines which method should be used in which patient. It would be necessary and valuable to develop an algorithm based on imaging findings in particular to improve the diagnostic accuracy, safety, and cost of the procedure. The investigators aimed to test the algorithm in an interventional study to increase the level of evidence in this study.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Image-Assısted Pleural Needle Biopsy or Medical Thoracoscopy: Which Method for Which Patient? A Randomızed Controlled Trial.
   Metintas M, Ak G, Yildirim H, Dundar E, et al · · 2024 · cited 10× · PMID 38554817 · DOI 10.1016/j.chest.2024.03.038