NCT05428709 (WISER-WIN) is a NA clinical trial of Acute Exercise in Breast Cancer, sponsored by Milton S. Hershey Medical Center.

Who is sponsoring NCT05428709?

NCT05428709 is sponsored by Milton S. Hershey Medical Center.

What drugs are being tested in NCT05428709?

Interventions in NCT05428709: Acute Exercise.

What condition does NCT05428709 study?

NCT05428709 studies Breast Cancer.

Is NCT05428709 still recruiting?

NCT05428709 is currently terminated. Last updated 21 July 2023.

Last reviewed 2023-07-21 · How we verify

NCT05428709: WISER-WIN

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Women In Steady Exercise Research - Window of Opportunity for Exercise and Tumor Biology

Terminated NA Last updated 21 July 2023

What this trial tests

NA trial testing Acute Exercise in Breast Cancer in 3 participants. Terminated before completion.

Timeline

1 February 2023

Primary endpoint
22 June 2023

29 June 2023

Quick facts

Lead sponsor	Milton S. Hershey Medical Center
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	basic science
Enrollment	3
Start date	1 February 2023
Primary completion	22 June 2023
Estimated completion	29 June 2023
Sites	1 location across United States

Drugs / interventions tested

Acute Exercise

Conditions studied

Breast Cancer — all drugs for Breast Cancer →

Sponsor

Milton S. Hershey Medical Center

Who can join

Adults 18 to 80, female only, with Breast Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The primary aim is to examine changes in tumor perfusion, oxygen saturation, and tumor physiology before and following acute physical activity in breast cancer patients. The secondary aim is to examine changes in circulating tumor DNA (ctDNA) levels before and following acute physical activity in breast cancer patients. The tertiary aim is to explore changes in circulating exerkines (cytokines and growth factors altered by exercise) before and following acute physical activity in breast cancer patients.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Beyond traditional biopsies: the emerging role of ctDNA and MRD on breast cancer diagnosis and treatment.
Sabit H, Attia MG, Mohamed N, Taha PS, et al · · 2025 · cited 4× · PMID 40050490 · DOI 10.1007/s12672-025-01940-6

Verify or expand the search:

Other trials of Acute Exercise

Trials testing the same drug.

NCT05319522 — The Relationship Between Irisin and Bone Health in Individuals With Spinal Cord Injury · NA · completed
NCT05170464 — The Acute Effects of Exercise and Caffeine on Working Memory During Acute Caffeine Deprivation · Phase 2, PHASE3 · completed

Other recruiting trials for Breast Cancer

Currently open trials in the same condition.

NCT06148038 — CBD for Breast Cancer Primary Tumors · Phase 1 · recruiting
NCT07405801 — A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus R · Phase 2 · recruiting
NCT07285993 — Detection and Outcomes in Metastatic Invasive Lobular Breast Cancer Through Novel F-18 FAP PET · Phase 2 · recruiting
NCT07510698 — Same-Day Awake Mastectomy With Immediate Breast Reconstruction for Patients With Breast Cancer · NA · recruiting
NCT06768931 — Biolosion Combined Standard Neoadjuvant Therapy to Treat Triple-negative Breast Cancer · Phase 2 · recruiting

Other Milton S. Hershey Medical Center trials

Trials by the same sponsor.

NCT05180552 — The HEALiX: Comparing the Efficacy of the HEALiX Device With Wrist Restraints in a Critical Care Setting · NA · withdrawn
NCT07461844 — Transdiagnostic Sleep and Circadian Treatment for Autistic Adults · NA · not yet recruiting
NCT06253858 — Ultrasound (US) Guided External Ventricular Catheter Placement · NA · not yet recruiting
NCT07225699 — IN PATIENTS WITH CORNEAL ABRASIONS TREATED WITH COLLAGEN CORNEAL SHIELDS IN THE EMERGENCY DEPARTMENT SETTING · NA · not yet recruiting
NCT07461168 — Penn State Emergency Medicine CarES: Care-partner Evaluation and Sourcing in the Emergency Department · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05428709 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Milton S. Hershey Medical Center
Last refreshed: 21 July 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05428709.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing