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NCT05424406: REACT
Role of Sleep Reactivity in Shift Work Disorder
NA trial testing Active phototherapy in Shift-work Disorder in 150 participants. Currently enrolling.
30 June 2027
Quick facts
| Lead sponsor | Henry Ford Health System |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | sequential |
| Masking | double |
| Primary purpose | other |
| Enrollment | 150 |
| Start date | 1 January 2023 |
| Primary completion | 30 June 2027 |
| Estimated completion | 1 October 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Active phototherapy
- Control phototherapy
- Cognitive Behavioral Therapy (CBT)
- Sleep education control
Conditions studied
- Shift-work Disorder — all drugs for Shift-work Disorder →
Sponsor
Henry Ford Health System — full company profile →
Who can join
18 and older, any sex, with Shift-work Disorder. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this project is to test sleep reactivity as an independent cause of Shift Work Disorder (SWD). The primary hypothesis is that those with high sleep reactivity will show persistent SWD symptoms after experimental reduction of circadian misalignment, which will then be mitigated with CBT.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05424406
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Shift-work Disorder
Currently open trials in the same condition.
- NCT06492109 — The Peripheral Blood Multi-Omics Study on Sleep Loss · NA · recruiting
- NCT06440434 — Effects of Morningness on Night Split Shift Performance · NA · active not recruiting
- NCT06288568 — Night Shift Work and Biomarkers of Obesity Risk in Hospital and Industry Workers · recruiting
- NCT05633498 — Self-help Book for Shift Work Related Problems · NA · recruiting
- NCT04869098 — Effects of an Evening PROtein PrEload on Metabolic Health in Night ShIfT Workers (PROPENSITy) · NA · recruiting
Other Henry Ford Health System trials
Trials by the same sponsor.
- NCT07450183 — Perioperative Cemiplimab for Resectable Non-Small Cell Lung Cancer With High PD-L1 · Phase 2 · not yet recruiting
- NCT07418853 — Comparison of Goniotomy Device Outcomes in Combined Phacoemulsification-goniotomy Surgeries · NA · not yet recruiting
- NCT06670287 — The Use of Multiple Sensors to Track Sleep in Nightshift Workers · NA · recruiting
- NCT07363525 — Michigan Initial Experience Using Tigertriever for Thrombectomy · not yet recruiting
- NCT07530172 — Radioembolization Versus External Radiation Therapy · Phase 2 · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05424406 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Henry Ford Health System
- Last refreshed: 14 October 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05424406.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing