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NCT05423002: CONE

Effect of Different Color Lights on the Internal Clock and Alertness in Humans

Status unknown NA Last updated 21 June 2022
What this trial tests

NA trial testing Flickering light stimuli in Light Flashing in 68 participants. Status unknown.

Timeline
20 June 2022
Primary endpoint
15 March 2023
15 September 2023

Quick facts

Lead sponsorUniversity of Basel
PhaseNA
StatusStatus unknown
Study typeINTERVENTIONAL
Allocationrandomized
Designcrossover
Maskingsingle
Primary purposebasic science
Enrollment68
Start date20 June 2022
Primary completion15 March 2023
Estimated completion15 September 2023
Sites1 location across Switzerland

Drugs / interventions tested

Conditions studied

Sponsor

University of Basel

Who can join

Adults 18 to 35, any sex, with Light Flashing. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The main aim of this study is to investigate the effects of cone-modulated light emitted from a visual display on human circadian physiology and cognitive performance in the evening.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Sex and Seasonal Variations in Melatonin Suppression and Alerting Response to Light.
    Fazlali F, Lazar R, Yahya F, Stefani O, et al · · 2025 · cited 3× · PMID 41230024 · DOI 10.1210/jendso/bvaf155
  2. Lack of strong evidence for cone photoreceptors' contribution to human melatonin suppression and alerting response to light.
    Fazlali F, Lazar R, Yahya F, Epple C, et al · · 2025 · cited 3× · PMID 40687802 · DOI 10.1016/j.isci.2025.112983

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Other University of Basel trials

Trials by the same sponsor.

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