NCT05421975: EASY MRI

Evaluating Airway Sarcoidosis Pathology With MRI

Terminated Last updated 29 April 2025

What this trial tests

trial in Sarcoidosis in 2 participants. Terminated before completion.

Timeline

28 June 2021

Primary endpoint
22 August 2023

22 August 2023

Quick facts

Lead sponsor	Sheffield Teaching Hospitals NHS Foundation Trust
Status	Terminated
Study type	OBSERVATIONAL
Enrollment	2
Start date	28 June 2021
Primary completion	22 August 2023
Estimated completion	22 August 2023
Sites	1 location across United Kingdom

Conditions studied

• Sarcoidosis — all drugs for Sarcoidosis →

Sponsor

Sheffield Teaching Hospitals NHS Foundation Trust

Who can join

18 and older, any sex, with Sarcoidosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Sarcoidosis is a condition where inflamed cells clump together to form granulomas, which can lead to inflammation or scarring. It can affect any organ of the body, but most commonly affects the lungs. Symptoms can be highly variable, and some patients have no symptoms where as others may develop fatigue or breathlessness. The causes of sarcoidosis are poorly understood. It commonly affects adults in their 30's or 40's.

Some patients present with symptoms suggestive of involvement in the airways, such as cough. Inhalers containing steroid are commonly used, but there is a poor understanding of which patients may benefit. Part of the problem is the lack of a sensitive way of measuring these effects and knowledge of how sarcoidosis affects the airways physiologically.

The investigators would like to know more about the disease process of sarcoidosis, particularly where it involves the airways. This study will use a number of techniques in order to better understand to disease process.

In order to assess whether sarcoidosis produces changes in airway ventilation (and whether these changes are stable or change over a short time period). This pilot study aims to recruit 6 patients who will have magnetic resonance imaging (MRI) with inhaled xenon gas. During this technique, xenon and nitrogen mixture is inhaled and during a subsequent breath-hold, images of the lungs are taken. This creates a detailed view of the lung airway tree, to explore how the disease affects the airways and deeper lung tissue.

This technique will be used alongside lung function tests, commonly performed in the laboratory setting and cardiopulmonary exercise testing, to see what happens in the lungs of this group of patients when they reach peak exercise capacity.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.