Last reviewed · How we verify
NCT05417659
Glycogen and Appetite
NA trial testing Exercise plus carbohydrate in Energy Intake in 15 participants. Completed in 30 August 2024.
15 March 2024
Quick facts
| Lead sponsor | University of Bath |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | quadruple |
| Primary purpose | basic science |
| Enrollment | 15 |
| Start date | 10 October 2022 |
| Primary completion | 15 March 2024 |
| Estimated completion | 30 August 2024 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Exercise plus carbohydrate
- Exercise plus niacin
- Placebo
Conditions studied
- Energy Intake — all drugs for Energy Intake →
Sponsor
University of Bath
Who can join
Adults 18 to 60, any sex, with Energy Intake. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Obesity is the outcome of chronic excessive energy intake and reduced energy expenditure leading to energy imbalance. It is a risk factor for many preventable diseases such as metabolic disease and its consequences such as type 2 diabetes and cardiovascular disease. Sedentary adults have been shown to have an increased appetite in excess of energy requirements and adults who are more active are able to better regulate energy intake. It is thought that carbohydrate availability and specifically hepatic glycogen utilisation during exercise is a regulator of appetite. However, the majority of research so far does not support this theory, potentially due to research not examining the tissue-specific link between glycogen use and appetite. The aim of this study is to assess whether altering substrate utilisation during exercise by suppressing lipolysis influences GLP-1 levels and caloric intake post exercise. Additionally, the study will explore if there is a tissue specific link between substrate utilisation and post exercise energy intake and examine potential sex differences.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Isolating the effects of carbohydrate and lipid availability on exercise-induced skeletal muscle signalling in males.
Bradshaw L, Cabañas AM, Spellanzon B, Hutchins KM, et al · · 2026 · cited 3× · PMID 41243363 · DOI 10.1113/jp289864
Verify or expand the search:
- PubMed search for NCT05417659
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Energy Intake
Currently open trials in the same condition.
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- NCT06432517 — Sources and Mechanisms of Energy Compensation · NA · recruiting
- NCT04148560 — Free-living Validation of the RFPM in Adolescents · NA · active not recruiting
Other University of Bath trials
Trials by the same sponsor.
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- NCT07472244 — Does the Development of the Repeated Bout Effect Depend on Oxidative Stress and Inflammation? · NA · recruiting
- NCT07099911 — Neuromuscular Electrical Stimulation and Glucose Control in Spinal Cord Injury · NA · recruiting
- NCT07027553 — Remote Exercise to Improve Physical Activity Levels and Markers of Heart Health in Cystic Fibrosis (RHH-CF) · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05417659 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Bath
- Last refreshed: 27 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05417659.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing