Who is sponsoring NCT05417009?

NCT05417009 is sponsored by Queen Mary University of London.

What drugs are being tested in NCT05417009?

Interventions in NCT05417009: trans-cutaneous auricular sensory stimulation.

What condition does NCT05417009 study?

NCT05417009 studies Ischemic Stroke, Thrombotic Stroke, Autonomic Dysfunction, Autonomic Imbalance.

Is NCT05417009 still recruiting?

NCT05417009 is currently completed. Last updated 14 July 2025.

Are results published for NCT05417009?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2025-07-14 · How we verify

NCT05417009: VANS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Autonomic Neuromodulation by Transcutaneous Nerve Stimulation in Acute Ischaemic Stroke.

Completed NA Results posted Last updated 14 July 2025

What this trial tests

NA trial testing trans-cutaneous auricular sensory stimulation in Ischemic Stroke in 36 participants. Completed in 21 July 2023.

Timeline

26 April 2023

Primary endpoint
21 July 2023

21 July 2023

Quick facts

Lead sponsor	Queen Mary University of London
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	36
Start date	26 April 2023
Primary completion	21 July 2023
Estimated completion	21 July 2023
Sites	1 location across United Kingdom

Drugs / interventions tested

trans-cutaneous auricular sensory stimulation

Conditions studied

Ischemic Stroke — all drugs for Ischemic Stroke →
Thrombotic Stroke — all drugs for Thrombotic Stroke →
Autonomic Dysfunction — all drugs for Autonomic Dysfunction →
Autonomic Imbalance — all drugs for Autonomic Imbalance →

Sponsor

Queen Mary University of London

Who can join

Adults 18 to 95, any sex, with Ischemic Stroke or Thrombotic Stroke. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Blood Pressure Variability Primary · 0-24h after mechanical thrombectomy

Coefficient of variation of systolic blood pressure

Group	Value	95% CI
Stimulation	0.106	± 0.029
Electrode Attachment Only.	0.107	± 0.027

Systolic Blood Pressure Variability. Secondary · 0-24h after mechanical thrombectomy

Systolic blood pressure standard deviation.

Group	Value	95% CI
Stimulation - n=18	14	± 5
Electrode Attachment Only - n=18	14	± 4

Diastolic Blood Pressure Variability Secondary · 24h after admission for mechanical thrombectomy

coefficient of variation- diastolic blood pressure

Group	Value	95% CI
Stimulation	0.136	± 0.05
Electrode Attachment Only.	0.127	± 0.04

Adverse events — posted to ClinicalTrials.gov

Time frame: From randomisation until 7 days after thrombectomy. Reporting threshold: 0%. Adverse-event reports describe events observed during the trial — not all are caused by the drug.

Stimulation - n=18

Serious: 0/18 (0%)

Deaths: 0/18

Electrode Attachment Only - n=18

Serious: 0/18 (0%)

Deaths: 2/18

Other adverse events (2 terms — click to expand)

Reaction	System	Stimulation - n=18	Electrode Attachment Only …
Skin irritation	Skin and subcutaneous tissue disorders	—	—
Anaesthetic complication	Respiratory, thoracic and mediastinal disorders	—	—

Data from ClinicalTrials.gov NCT05417009 adverse events section.

Sponsor's own description

Autonomic modulation by transcutaneous vagal nerve stimulation in acute ischaemic stroke requiring mechanical thrombectomy: a phase IIa, sham controlled randomised trial.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Transauricular nerve stimulation in acute ischaemic stroke requiring mechanical thrombectomy: Protocol for a phase 2A, proof-of-concept, sham-controlled randomised trial.
Ackland GL, Martin T, Joseph M, Dias P, et al · · 2023 · cited 1× · PMID 38134136 · DOI 10.1371/journal.pone.0289719
Transauricular Vagus Nerve Stimulation in Acute Ischaemic Stroke Requiring Mechanical Thrombectomy: Sham-Controlled, Randomised Device Trial.
Ackland GL, Crane D, Ahuja S, Patel A, et al · · 2025 · PMID 41455014 · DOI 10.1007/s12975-025-01404-7

Verify or expand the search:

Other recruiting trials for Ischemic Stroke

Currently open trials in the same condition.

NCT07509645 — Efficacy and Safety of Interleukin-6 Receptor Inhibitor Combined With Endovascular Treatment in Patients With Acute Post · Phase 3 · recruiting
NCT07375953 — Repeated Intravenous Thrombolysis for Ischemic Stroke Within 3.0 Hours of Onset With Tenecteplase (RITIS-TNK) · Phase 2 · recruiting
NCT07375966 — Repeated Intravenous Thrombolysis for Ischemic Stroke With Medium to Large Vessel Occlusion Presenting Within 4.5 Hours · Phase 2 · recruiting
NCT07491952 — Continuous Dual Aspiration Technique With Zoom System for Stroke · recruiting
NCT07371455 — A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LWP779 in Healthy Participants · Phase 1 · recruiting

Other Queen Mary University of London trials

Trials by the same sponsor.

NCT07246005 — LVT DURATION: Pilot Study of Anticoagulation Duration for Left Ventricular Thrombus · Phase 2 · not yet recruiting
NCT07165678 — CTCA Prior to Invasive Angiography in Post-Bypass Patients (BYPASS CTCA 2) · NA · not yet recruiting
NCT06937372 — Delivery and Implementation of a Randomised Crossover Trial on Thrombosis · NA · not yet recruiting
NCT06600438 — Slow-SPEED UK: A Double-Blind Randomised Feasibility Trial · NA · not yet recruiting
NCT06987045 — Trans and Non-binary Prostate-Specific Antigen Reference Interval Determination Study · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05417009 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Queen Mary University of London
Last refreshed: 14 July 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05417009.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing