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NCT05416515

A Study of Fisetin to Treat Carpal Tunnel Syndrome

Completed Phase 2 Results posted Last updated 24 December 2025
What this trial tests

Phase 2 trial testing Fisetin in Carpal Tunnel Syndrome in 40 participants. Completed in 24 January 2025.

Timeline
9 October 2022
Primary endpoint
31 December 2024
24 January 2025

Quick facts

Lead sponsorPeter C. Amadio, M.D.
PhasePhase 2
StatusCompleted
Study typeINTERVENTIONAL
Allocationna
Designsingle group
Maskingnone
Primary purposetreatment
Enrollment40
Start date9 October 2022
Primary completion31 December 2024
Estimated completion24 January 2025
Sites1 location across United States

Drugs / interventions tested

Conditions studied

Sponsor

Peter C. Amadio, M.D.

Who can join

Adults 21 to 80, any sex, with Carpal Tunnel Syndrome. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Change in Boston Carpal Tunnel Syndrome (BCTQ) Score Primary · Baseline, 60 days

The Boston Carpal Tunnel Syndrome questionnaire (BCTQ) assesses symptom severity and overall function of subjects with Carpel Tunnel Syndrome. The questionnaire consists of two sections: 1. Symptom Severity (11 questions) and 2. Functional Status (8 questions). Subjects are asked to rate each question on a scale of 1 to 5. The mean score for each section is calculated by summing the individual question responses and diving by the number of questions resulting in a total score ranging from 1 to 5, with higher scores indicating greater symptom severity and dysfunction.

GroupValue95% CI
Carpal Tunnel Syndrome-0.5± 0.6

Adverse events — posted to ClinicalTrials.gov

Time frame: Adverse events were collected from the time of investigational product administration through post-treatment follow up, approximately 180 days.. Reporting threshold: 0%. Adverse-event reports describe events observed during the trial — not all are caused by the drug.

Carpal Tunnel Syndrome
Serious: 0/40 (0%)
Deaths: 0/40
Other adverse events (8 terms — click to expand)

ReactionSystemCarpal Tunnel Syndrome
Increased PainGeneral disorders
Surgery due to Continued PainGeneral disorders
Increased Symptom SeverityGeneral disorders
Weight GainInvestigations
Loose BowelsGastrointestinal disorders
C-Reactive Protein Level IncreasedInvestigations
Leg CrampingMusculoskeletal and connective tissue disorders
HeadachesNervous system disorders

Data from ClinicalTrials.gov NCT05416515 adverse events section.

Sponsor's own description

This research study is being conducted to investigate the safety and effectiveness of the drug Fisetin for mild or moderate carpal tunnel syndrome (CTS).

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Past and Future Directions for Research on Cellular Senescence.
    Zhu Y, Anastasiadis ZP, Espindola Netto JM, Evans T, et al · · 2024 · cited 22× · PMID 37734865 · DOI 10.1101/cshperspect.a041205
  2. Senescence in the bone marrow microenvironment: A driver in development of therapy-related myeloid neoplasms.
    Guilatco AJ, Shah MV, Weivoda MM. · · 2024 · cited 3× · PMID 39072049 · DOI 10.1016/j.jbo.2024.100620
  3. The potential for senotherapy as a novel approach to extend life quality in veterinary medicine.
    Williams ZJ, Chow L, Dow S, Pezzanite LM. · · 2024 · cited 3× · PMID 38812556 · DOI 10.3389/fvets.2024.1369153
  4. Insights into the therapeutic strategies for aging and aging-associated diseases.
    Dong R, Wu Q, Kan J, Fu C, et al · · 2026 · PMID 42225652 · DOI 10.1038/s41392-026-02662-z
  5. Exploring the Senotherapeutic Potential of Polyphenols in Aging and Disease: A Literature Review.
    Braučič Mitrovic L, Semen KO. · · 2026 · PMID 42074288 · DOI 10.3390/ijms27083651
  6. Beneficial Effects of Fisetin, a Senotherapeutic Compound, in Women's Reproductive Health and Diseases: Evidence from In Vitro to Clinical Studies.
    El Sayed S, Saiyed D, Macri VI, Asamoah-Mensah A, et al · · 2026 · PMID 41683217 · DOI 10.3390/nu18030393

Verify or expand the search:

Other trials of Fisetin

Trials testing the same drug.

Other recruiting trials for Carpal Tunnel Syndrome

Currently open trials in the same condition.

Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05416515.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing