NCT05415605: LUNGSTRAIN

Ultrasound Evaluation of Alveolar Stress by Measurement of Ultrasound Pleural Strain in Healthy Subjects

Completed NA Last updated 4 December 2025

What this trial tests

NA trial testing Lung Strain in Ultrasound Strain Measurement in 30 participants. Completed in 27 July 2022.

Timeline

24 July 2022

Primary endpoint
27 July 2022

27 July 2022

Quick facts

Lead sponsor	Centre Hospitalier Universitaire de Nīmes
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	other
Enrollment	30
Start date	24 July 2022
Primary completion	27 July 2022
Estimated completion	27 July 2022
Sites	1 location across France

Drugs / interventions tested

• Lung Strain

Conditions studied

• Ultrasound Strain Measurement — all drugs for Ultrasound Strain Measurement →

Sponsor

Centre Hospitalier Universitaire de Nīmes

Who can join

Adults 18 to 50, any sex, with Ultrasound Strain Measurement. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In the critical patient, lung ultrasound is routinely performed for acute respiratory distress, adult respiratory distress syndrome and for hemodynamic evaluation. Its diagnostic performance is superior to that of chest radiography in the context of pleuropulmonary parenchymal pathologies. The search for lung sliding is performed to diagnose a pneumothorax or to search for the correct placement of the endotracheal intubation tube. However, this analysis is qualitative and is sometimes difficult to interpret. At present, there is no global evaluation technique at the patient's bed allowing to analyze simultaneously the alveolar recruitment, the pulmonary over-distension and the quality of the lung sliding, whereas the pulmonary damage is most often heterogeneous. The justification of our research project is based on the need to develop and validate a means of global and regional quantification of the mechanical and aeration properties of the lung parenchyma by the analysis of the acoustic markers of the pleura (pleural strain) by the ultrasound technique of speckle tracking. The aim is to establish the normal values of the pleural strain in healthy volunteers, in spontaneous ventilation and then in non-invasive mechanical ventilation, in order to vary the lung volume.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Pleural lung sliding quantification using a speckle tracking technology: A feasibility study on 30 healthy volunteers.
   Duclos G, Marecal L, Resseguier N, Postzich M, et al · · 2024 · cited 2× · PMID 38968827 · DOI 10.1016/j.cmpb.2024.108316