Last reviewed · How we verify
NCT05414045
Autologous Testicular Tissue Transplantation
NA trial testing Autologous testicular tissue transplantation of prepubertal frozen testicular tissue in Cancer in 5 participants. Currently enrolling.
29 July 2030
Quick facts
| Lead sponsor | Universitair Ziekenhuis Brussel |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 5 |
| Start date | 22 November 2024 |
| Primary completion | 29 July 2030 |
| Estimated completion | 29 October 2030 |
| Sites | 1 location across Belgium |
Drugs / interventions tested
- Autologous testicular tissue transplantation of prepubertal frozen testicular tissue
Conditions studied
- Cancer — all drugs for Cancer →
- Sickle Cell Thalassemia — all drugs for Sickle Cell Thalassemia →
- Hematologic Diseases — all drugs for Hematologic Diseases →
Sponsor
Universitair Ziekenhuis Brussel — full company profile →
Who can join
Adults 18 to 50, male only, with Cancer or Sickle Cell Thalassemia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Freezing testicular tissue of prepubertal boys is a method for preserving spermatogonial stem cells (SSCs) in case of imminent gonadotoxic treatment during childhood. In case of total azoospermia in adulthood and presence of a childwish, the investigators intend to perform the first in men autologous testicular tissue transplantation to restore fertility.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05414045
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05414045 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Universitair Ziekenhuis Brussel
- Last refreshed: 3 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05414045.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing