NCT05412095: MUSCA

Evaluation of the Prognostic Value of Preoperative Quadriceps and Respiratory Muscle Thickness by Ultrasound Measurement in Cardiac and Thoracic Surgery Patients

Completed Last updated 29 January 2026

What this trial tests

trial testing Ultrasound of the abdominal wall muscles in Cardiac Surgery With Extracorporeal Circulation in 301 participants. Completed in 26 September 2023.

Timeline

31 May 2022

Primary endpoint
26 September 2023

26 September 2023

Quick facts

Lead sponsor	Centre Hospitalier Universitaire Dijon
Status	Completed
Study type	OBSERVATIONAL
Enrollment	301
Start date	31 May 2022
Primary completion	26 September 2023
Estimated completion	26 September 2023
Sites	1 location across France

Drugs / interventions tested

• Ultrasound of the abdominal wall muscles
• Ultrasound quadricipital
• Ultrasound of the diaphragm
• Ultrasound of the inter-costal muscles
• Ultrasound of the inter-costal muscles

Conditions studied

• Cardiac Surgery With Extracorporeal Circulation — all drugs for Cardiac Surgery With Extracorporeal Circulation →
• Thoracic Surgery — all drugs for Thoracic Surgery →

Sponsor

Centre Hospitalier Universitaire Dijon

Who can join

65 and older, any sex, with Cardiac Surgery With Extracorporeal Circulation or Thoracic Surgery. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Cardiac and thoracic surgery are major procedures. In order to estimate the operative risk, many scores have been developed, including the Euroscore 2 in cardiac surgery. However, the Euroscore has limitations since it does not assess all the parameters that may influence postoperative complications, such as the patient's general condition or the status of his or her functional reserves.

However, it has been shown that the preoperative functional reserves have a significant impact on the patient's risk of developing postoperative complications following major surgery. In addition, there is a strong association between cardiac failure and a well-described decrease in peripheral muscle lean mass (sarcopenia) in patients older than 65 years.

Usually, a nutritional assessment is performed during the pre-anesthesia consultation. This assessment is based on clinical and biological criteria that are not totally predictive of the patient's functional reserve status.

Lean body mass (muscle) is a well-validated marker for the assessment of patients' functional reserves. However, the techniques used to date are complex and require radiation.

This study aims to use ultrasound of muscle groups (respiratory muscles - Quadriceps muscle - Diaphragm) to study the relationship between preoperative muscle mass and postoperative complications in patients over 65 years of age undergoing cardiac or thoracic surgery.

This is a prospective observational study to be conducted at the Dijon University Hospital by the cardiovascular anesthesia-intensive care department. A total of 300 patients will participate in this study, and we have planned to complete the project over a 2-year period. The participating patients (if they do not present any exclusion criteria and are not opposed to inclusion) will be included and undergo a muscle ultrasound in the cardiovascular surgery department or the thoracic and pulmonary surgery department the day before their intervention.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.