55 and older, any sex, with Mild Cognitive Impairment or Alzheimer Disease. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Melatonin LevelsPrimary· post-intervention (60 minutes) on each night of intervention (one night a week for 5 weeks)
Saliva samples collected for melatonin levels for the different conditions. Blue light (λmax = 451 nm) on axis and off axis: for each narrowband source, designated on-axis or off-axis, will have distinct lighting distribution patterns but calibrated to deliver the same targeted levels of circadian light (CLA) and circadian stimulus (CS) at the eye.
Green light (λmax = 522 nm) on and off axis: for each narrowband source, designated on-axis or off-axis, will have distinct lighting distribution patterns but calibrated to deliver the same targeted levels of circadian light (CLA) and circadian sti
Blue light (λmax = 451 nm) on axis
Group
Value
95% CI
Mild Cognitive Impairment
0.89
± 0.49
Healthy Control
0.84
± 0.51
Blue light (λmax = 451 nm) off axis
Group
Value
95% CI
Mild Cognitive Impairment
0.9
± 0.46
Healthy Control
0.68
± 0.21
Green light (λmax = 522 nm) on axis
Group
Value
95% CI
Mild Cognitive Impairment
0.73
± 0.14
Healthy Control
0.73
± 0.3
Green light (λmax = 522 nm) off axis
Group
Value
95% CI
Mild Cognitive Impairment
0.82
± 0.39
Healthy Control
0.79
± 0.24
Dim Light
Group
Value
95% CI
Mild Cognitive Impairment
1.53
± 0.7
Healthy Control
1.27
± 0.3
Sponsor's own description
The purpose of this research study is to investigate the relationship between light, the thickness of the pigment at the back of your eye, melatonin levels, and memory. The study will investigate whether changing light distribution pattern from "on-axis"' (i.e., directed along the eye's visual axis to the fovea) to "off-axis" (i.e., directed on the periphery of the eye's visual axis) impact melatonin suppression in 24 mild cognitive impairment participants and 24 healthy, age-matched controls.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
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Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Icahn School of Medicine at Mount Sinai
Last refreshed: 24 June 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05411822.