Who is sponsoring NCT05406297?

NCT05406297 is sponsored by Lithuanian University of Health Sciences.

What drugs are being tested in NCT05406297?

Interventions in NCT05406297: pressure-temperature sensor guidewire-based measurement.

What condition does NCT05406297 study?

NCT05406297 studies STEMI - ST Elevation Myocardial Infarction, Microvascular Coronary Artery Disease.

Is NCT05406297 still recruiting?

NCT05406297 is currently completed. Last updated 16 August 2022.

Last reviewed 2022-08-16 · How we verify

NCT05406297: TAMIR

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Impact of TMAO Serum Levels on Hyperemic IMR in STEMI Patients

Completed Last updated 16 August 2022

What this trial tests

trial testing pressure-temperature sensor guidewire-based measurement in STEMI - ST Elevation Myocardial Infarction in 400 participants. Completed in 1 August 2022.

Timeline

12 January 2021

Primary endpoint
1 July 2022

1 August 2022

Quick facts

Lead sponsor	Lithuanian University of Health Sciences
Status	Completed
Study type	OBSERVATIONAL
Enrollment	400
Start date	12 January 2021
Primary completion	1 July 2022
Estimated completion	1 August 2022
Sites	1 location across Lithuania

Drugs / interventions tested

pressure-temperature sensor guidewire-based measurement

Conditions studied

STEMI - ST Elevation Myocardial Infarction — all drugs for STEMI - ST Elevation Myocardial Infarction →
Microvascular Coronary Artery Disease — all drugs for Microvascular Coronary Artery Disease →

Sponsor

Lithuanian University of Health Sciences

Who can join

40 and older, any sex, with STEMI - ST Elevation Myocardial Infarction or Microvascular Coronary Artery Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite of dietary choline, L-carnitine, and phosphatidylcholine-rich foods. On the basis of experimental studies and patients with prevalent disease, elevated plasma TMAO may increase risk of atherosclerotic cardiovascular disease (ASCVD). However, to our knowledge, no data is available on its impact on coronary microcirculation.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Impact of Coronary Microvascular Dysfunction on Functional Left Ventricular Remodeling and Diastolic Dysfunction.
Aldujeli A, Tsai TY, Haq A, Tatarunas V, et al · · 2024 · cited 14× · PMID 38686863 · DOI 10.1161/jaha.123.033596
The Impact of Microvascular Resistance Reserve on the Outcome of Patients With STEMI.
Tsai TY, Aldujeli A, Haq A, Knokneris A, et al · · 2024 · cited 13× · PMID 38752970 · DOI 10.1016/j.jcin.2024.03.024
The impact of primary percutaneous coronary intervention strategies during ST-elevation myocardial infarction on the prevalence of coronary microvascular dysfunction.
Aldujeli A, Haq A, Tsai TY, Grabauskyte I, et al · · 2023 · cited 6× · PMID 37973856 · DOI 10.1038/s41598-023-47343-x
Trimethylamine N-Oxide as a Biomarker for Left Ventricular Diastolic Dysfunction and Functional Remodeling After STEMI.
Tsai TY, Aldujeli A, Haq A, Murphy P, et al · · 2025 · cited 1× · PMID 40244252 · DOI 10.3390/ijms26073400

Verify or expand the search:

Other recruiting trials for STEMI - ST Elevation Myocardial Infarction

Currently open trials in the same condition.

NCT07160491 — Early Thrombolysis Guided by AI-Assisted App in Patients With STEMI · NA · recruiting
NCT06013020 — Century Clot-Guided Prophylactic Rivaroxaban for Post STEMI Complicating Left Ventricular Thrombus · Phase 4 · recruiting
NCT06384846 — AI Algorithms in Prediction of ACS Based on Leukocyte Properties · recruiting
NCT04436978 — What is the Optimal Antithrombotic Strategy in Patients With Atrial Fibrillation Undergoing PCI? · Phase 4 · recruiting
NCT05800951 — Can Escalation Reduce Acute Myocardial Infarction Mortality in Cardiogenic Shock · active not recruiting

Other Lithuanian University of Health Sciences trials

Trials by the same sponsor.

NCT07477873 — Evaluation of Emotional Responses Using the I-Motions System and Self-assessment Questionnaires, and Assessment of Posto · NA · enrolling by invitation
NCT07476976 — Characteristics of the Functional State of the Musculoskeletal System, Body Awareness, and Quality of Life in Individual · enrolling by invitation
NCT07284446 — Depressive Symptoms, Cognitive Impairment, and Outcomes in Hospitalized Chronic Heart Failure Patients · recruiting
NCT07097675 — The Change in Psychoemotional State of Individuals With Dementia Syndrome Applying Art Therapy · NA · not yet recruiting
NCT06800222 — Effectiveness of Modern Physical Agents in the Treatment of Pelvic Floor Dysfunctions · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05406297 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Lithuanian University of Health Sciences
Last refreshed: 16 August 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05406297.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing