NCT05403593 (RESCUE-ICAS) is a clinical trial of No Intervention in Intracranial Stenosis, sponsored by Medical University of South Carolina.

Who is sponsoring NCT05403593?

NCT05403593 is sponsored by Medical University of South Carolina.

What drugs are being tested in NCT05403593?

Interventions in NCT05403593: No Intervention.

What condition does NCT05403593 study?

NCT05403593 studies Intracranial Stenosis, Large Vessel Occlusion, Mechanical Thrombectomy.

Is NCT05403593 still recruiting?

NCT05403593 is currently completed. Last updated 20 September 2024.

Last reviewed 2024-09-20 · How we verify

NCT05403593: RESCUE-ICAS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Registry of Emergent Large VeSsel OCclUsion DuE to IntraCranial AtherosclerosiS

Completed Last updated 20 September 2024

What this trial tests

trial testing No Intervention in Intracranial Stenosis in 600 participants. Completed in 14 June 2024.

Timeline

15 December 2021

Primary endpoint
5 March 2024

14 June 2024

Quick facts

Lead sponsor	Medical University of South Carolina
Status	Completed
Study type	OBSERVATIONAL
Enrollment	600
Start date	15 December 2021
Primary completion	5 March 2024
Estimated completion	14 June 2024
Sites	19 locations across Italy, Saudi Arabia, Germany, Switzerland, Portugal, United States

Drugs / interventions tested

No Intervention

Conditions studied

Intracranial Stenosis — all drugs for Intracranial Stenosis →
Large Vessel Occlusion — all drugs for Large Vessel Occlusion →
Mechanical Thrombectomy — all drugs for Mechanical Thrombectomy →

Sponsor

Medical University of South Carolina

Who can join

Adults 18 to 90, any sex, with Intracranial Stenosis or Large Vessel Occlusion. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of this study is to develop an international multicenter registry of patient data and outcomes for patients undergoing mechanical thrombectomy for emergent large vessel occlusion with residual underlying stenosis following successful revascularization.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

Outcomes of Adjunct Emergent Stenting Versus Mechanical Thrombectomy Alone: The RESCUE-ICAS Registry.
Al Kasab S, Almallouhi E, Jumaa M, Inoa V, et al · · 2025 · cited 15× · PMID 39576761 · DOI 10.1161/strokeaha.124.049038
Clinico-radiological features of intracranial atherosclerosis-related large vessel occlusion prior to endovascular treatment.
Rodrigo-Gisbert M, García-Tornel A, Requena M, Vielba-Gómez I, et al · · 2024 · cited 5× · PMID 38316891 · DOI 10.1038/s41598-024-53354-z
RESCUE-ICAS: Rationale and Study Design.
Almallouhi E, de Havenon A, Asi K, Limaye K, et al · · 2023 · cited 1× · PMID 41583676 · DOI 10.1161/svin.122.000530
Effect of Acute Intracranial Stenting in Patients With Successful Reperfusion Following Large-Vessel Occlusion Secondary to Intracranial Atherosclerosis: Secondary Analyses of the RESCUE-ICAS Study.
Nguyen S, de Havenon A, Almallouhi E, Jumaa MA, et al · · 2026 · PMID 41815302 · DOI 10.1161/svin.125.001841
Unmet Needs in Acute Ischemic Stroke: Overcoming Recalcitrant Clots.
Mirza M, Ulfert C, Ulfert C, McCarthy R, et al · · 2025 · PMID 40576345 · DOI 10.1097/crd.0000000000000977

Verify or expand the search:

Other trials of No Intervention

Trials testing the same drug.

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NCT07521917 — Child Abuse and Neglect Awareness Training in Nursing Students · NA · not yet recruiting
NCT07319832 — A Study of Teduglutide in Chinese Children and Teenagers With Short Bowel Syndrome · recruiting
NCT07425574 — A Study to Learn How Stargardt-type Eye Conditions Progress in Children and Adults · recruiting

Other recruiting trials for Intracranial Stenosis

Currently open trials in the same condition.

NCT07072026 — Endovascular Recanalization for Symptomatic Chronic Intradural Occlusions · recruiting

Other Medical University of South Carolina trials

Trials by the same sponsor.

NCT06491264 — Multiparameter Optimized tES for Memory in Aging · NA · withdrawn
NCT07513389 — Omission of Postoperative Radiation in HPV-Associated Oropharyngeal Cancer Using ctHPVDNA Surveillance (OPERATION) · Phase 2 · not yet recruiting
NCT03101917 — Microtable® Method for Cochlear Implantation Investigational Device Exemption (IDE) · NA · not yet recruiting
NCT07149207 — Intraoperative Molecular Imaging Using ICG for Head and Neck Tumors · Phase 2 · recruiting
NCT06148038 — CBD for Breast Cancer Primary Tumors · Phase 1 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05403593 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Medical University of South Carolina
Last refreshed: 20 September 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05403593.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing